DegronMD - P23760(PAX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T359P	TCGA-AP-A056	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.T359P	DO43971	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.S454I	TCGA-B5-A11E	UCEC	TCGA	PPTY	ITCH	450:453	Mutation rewiring degron network	0.3056
p.S454I	TCGA-E6-A1LX	UCEC	TCGA	PPTY	ITCH	450:453	Mutation rewiring degron network	0.3056
p.P451H	TCGA-D3-A3CB	SKCM	TCGA	PPTY	ITCH	450:453	Mutation altering degron motif	0.7694
p.S358N	TCGA-E6-A1LX	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.S358N	DO41020	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.C449Y	TCGA-G4-6302	COAD	TCGA	PPTY	ITCH	450:453	Mutation rewiring degron network	0.3056
p.V339A	DO223394	CLLE	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.C448Y	DO8778	COAD	ICGC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.2778
p.P461H	DO230343	COCA	ICGC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.1111
p.S458I	DO222884	COCA	ICGC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.1944
p.S358R	DO228971	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.N347K	DO229027	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.3056
p.T343K	DO229036	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.G456S	DO50970	LICA	ICGC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.25
p.I344F	DO228222	MALY	ICGC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222
p.V462D	DO32904	PACA	ICGC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.0833
p.P450H	DO47386	SKCM	ICGC	PPTY	ITCH	450:453	Mutation altering degron motif	0.7694
p.S453I	DO41020	UCEC	ICGC	PPTY	ITCH	450:453	Mutation altering degron motif	0.7341
p.S453I	DO41644	UCEC	ICGC	PPTY	ITCH	450:453	Mutation altering degron motif	0.7341
p.T456A	SIDM00845	Burkitt's Lymphoma	GDSC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.25
p.P348A	SIDM00845	Burkitt's Lymphoma	GDSC	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.6392
p.S454N	SIDM00498	Colorectal Carcinoma	GDSC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.3056
p.S454N	SNU-C5	large intestine	COSMIC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.3056
p.D440Y	SIDM01494	Glioblastoma	GDSC	PPTY	ITCH	450:453	Mutation rewiring degron network	0.0556
p.T455A	ACH-000786	Lymphoma	CCLE	PPTY	ITCH	450:453	Mutation rewiring degron network	0.2778
p.P347A	ACH-000786	Lymphoma	CCLE	PDSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.3056
p.S453N	ACH-000970	Colon/Colorectal Cancer	CCLE	PPTY	ITCH	450:453	Mutation altering degron motif	0.7069
p.S453N	SNU-C5	large intestine	COSMIC	PPTY	ITCH	450:453	Mutation altering degron motif	0.7069
p.P450T	ACH-000997	Colon/Colorectal Cancer	CCLE	PPTY	ITCH	450:453	Mutation altering degron motif	0.7031

Kaplan plot for PAX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAX3

UniProt ID: P23760

Entrez ID: 5077

Protein name: Paired box protein Pax-3 (HuP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAX3 in