DegronMD - Q2T9L4(INSYN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P121L	SIDM00776	Colorectal Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.P121L	SIDM01097	Other Solid Cancers	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.P121L	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.P121L	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.P121L	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.P121L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.D72H	SIDM01175	Other Sarcomas	GDSC	VSSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.D72H	SW684	soft tissue	COSMIC	VSSTS	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1667
p.R132L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1111
p.R132L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	138:140	Mutation rewiring degron network	0.1667
p.R132L	SLVL	haematopoietic and lymphoid tissue	COSMIC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1111
p.R132L	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	138:140	Mutation rewiring degron network	0.1667
p.T146M	SIDM00178	Melanoma	GDSC	VETPDSS	DEG_SCF_FBW7_1	154:160	Mutation blocking phosphorylation signal	0.5556
p.T146M	SIDM00178	Melanoma	GDSC	DYR	CBL_MET	138:140	Mutation blocking phosphorylation signal	0.6111
p.T146M	SIDM01575	Plasma Cell Myeloma	GDSC	VETPDSS	DEG_SCF_FBW7_1	154:160	Mutation blocking phosphorylation signal	0.5556
p.T146M	SIDM01575	Plasma Cell Myeloma	GDSC	DYR	CBL_MET	138:140	Mutation blocking phosphorylation signal	0.6111
p.R140H	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	138:140	Mutation altering degron motif	0.8244
p.R140H	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	138:140	Mutation altering degron motif	0.8244
p.P137H	SIDM01770	Gastric Carcinoma	GDSC	DYR	CBL_MET	138:140	Mutation rewiring degron network	0.3056
p.R132G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1111
p.R132G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	138:140	Mutation rewiring degron network	0.1667
p.S130A	T47D	breast	COSMIC	VSTPSDS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1667
p.S130A	T47D	breast	COSMIC	DYR	CBL_MET	138:140	Mutation rewiring degron network	0.1111

Kaplan plot for INSYN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INSYN1

UniProt ID: Q2T9L4

Entrez ID: 388135

Protein name: Inhibitory synaptic factor 1 (InSyn1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INSYN1 in