DegronMD

Uniprot ID: Q2T9L4

Source protein: Inhibitory synaptic factor 1

Source gene: INSYN1

Class: DEG_SCF_FBW7_1

Location: 118:124

E3 ligase: FBXW7

DEGRON score: 0.8925

ASA_SCORE: 61.2857

COIL: 0.8617

CONS_SCORE: 0.7571

DSS_SCORE: 0.4642

HELIX: 0.0759

FCONS_SCORE: 1.0013

RIG_SCORE: 0.6829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P121L	SIDM00776	Colorectal Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.7582
p.P121L	SIDM01097	Other Solid Cancers	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.7582
p.P121L	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.7582
p.P121L	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.7582
p.P121L	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.7582
p.P121L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.7582
p.R132L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.1111
p.R132L	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPSDS	DEG_SCF_FBW7_1	0.1111
p.R132G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VSTPSDS	DEG_SCF_FBW7_1	0.1111
p.S130A	T47D	breast	COSMIC	VSTPSDS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2T9L4	Inhibitory synaptic factor 1	DEG_SCF_FBW7_1	118:124	VSTPSDS	FBXW7	0.8925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons