DegronMD

Uniprot ID: Q2T9L4

Source protein: Inhibitory synaptic factor 1

Source gene: INSYN1

Class: DEG_SPOP_SBC_1

Location: 78:82

E3 ligase: SPOP

DEGRON score: 0.9827

ASA_SCORE: 75.6

COIL: 0.9056

CONS_SCORE: 0.9449

DSS_SCORE: 0.4961

HELIX: 0.0692

FCONS_SCORE: 1.2176

RIG_SCORE: 0.7026

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D72H	SIDM01175	Other Sarcomas	GDSC	VSSTS	DEG_SPOP_SBC_1	0.1667
p.D72H	SW684	soft_tissue	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.1667

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Drug responses associated with INSYN1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VSSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	664:668	VSSTS	SPOP	0.9924	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	610:614	VSSTS	SPOP	0.92	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	655:659	VSSTS	SPOP	0.9712	More...
P32246	C-C chemokine receptor type 1	DEG_SPOP_SBC_1	339:343	VSSTS	SPOP	0.8417	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	150:154	VSSTS	SPOP	0.7703	More...
P98194	Calcium-transporting ATPase type 2C member 1	DEG_SPOP_SBC_1	909:913	VSSTS	SPOP	0.7013	More...
Q14444	Caprin-1	DEG_SPOP_SBC_1	435:439	VSSTS	SPOP	0.9876	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	446:450	VSSTS	SPOP	0.9902	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	463:467	VSSTS	SPOP	0.9197	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	608:612	VSSTS	SPOP	0.9192	More...
Q7Z7J5	Developmental pluripotency-associated protein 2	DEG_SPOP_SBC_1	44:48	VSSTS	SPOP	0.9982	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	2497:2501	VSSTS	SPOP	0.9395	More...
Q5JQS6	Germinal center-associated signaling and motility-like protein	DEG_SPOP_SBC_1	50:54	VSSTS	SPOP	0.9925	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	78:82	VSSTS	SPOP	0.9827	More...
Q6TDP4	Kelch-like protein 17	DEG_SPOP_SBC_1	637:641	VSSTS	SPOP	0.7137	More...
Q9NZQ3	NCK-interacting protein with SH3 domain	DEG_SPOP_SBC_1	218:222	VSSTS	SPOP	0.9877	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	1675:1679	VSSTS	SPOP	0.8575	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1552:1556	VSSTS	SPOP	0.936	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	984:988	VSSTS	SPOP	0.9993	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	667:671	VSSTS	SPOP	0.9399	More...
O15544	Protein GR6	DEG_SPOP_SBC_1	16:20	VSSTS	SPOP	0.9463	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	88:92	VSSTS	SPOP	0.985	More...
Q8N9Q2	Protein SREK1IP1	DEG_SPOP_SBC_1	44:48	VSSTS	SPOP	0.9807	More...
C9J202	Putative glycosyltransferase ALG1L2	DEG_SPOP_SBC_1	78:82	VSSTS	SPOP	0.7087	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1217:1221	VSSTS	SPOP	0.755	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSTS

Degron related mutations and impact score

Drug responses associated with INSYN1 mutations

All proteins holding degron of VSSTS