DegronMD - Q9HCM4(EPB41L5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P607S	TCGA-A6-5665	COAD	TCGA	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0556
p.P607S	TCGA-BR-8680	STAD	TCGA	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0556
p.P607S	DO9756	COAD	ICGC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0556
p.P607S	DO47769	STAD	ICGC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0556
p.M617I	TCGA-BH-A0DK	BRCA	TCGA	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.6507
p.M617I	DO1305	BRCA	ICGC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.6507
p.R664W	TCGA-CM-6169	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.R664W	DO8344	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.P702Q	TCGA-D3-A2JP	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1389
p.P702Q	DO47407	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1389
p.F705L	TCGA-DK-A6AW	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.2222
p.F705L	TCGA-EO-A22U	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.2222
p.F705L	DO48566	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.2222
p.F705L	DO43755	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.2222
p.E634K	TCGA-VS-A9UP	CESC	TCGA	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0556
p.E634K	DO219737	CESC	ICGC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0556
p.E614Q	DO225140	BRCA	ICGC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.25
p.W665R	DO234191	ESAD	ICGC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1667
p.W665C	DO228971	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1667
p.V667F	DO229031	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1111
p.Q654H	DO229037	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.A703G	DO230524	LUSC	ICGC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1667
p.L669F	DO36556	READ	ICGC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.0556
p.L608F	DO218874	SKCA	ICGC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation rewiring degron network	0.0833
p.Q654L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM01156	Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00504	Glioma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00185	Melanoma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00266	Ewing's Sarcoma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM01165	Pancreatic Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00482	Chronic Myelogenous Leukemia	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM01220	Glioma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00876	Non-Cancerous	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM01650	Non-Cancerous	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00877	Breast Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.Q654L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.S712G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.6993
p.S712G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.6993
p.M617K	SIDM01112	Osteosarcoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.M617K	SIDM00650	Small Cell Lung Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.M617K	SIDM00032	Bladder Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.M617K	SIDM00882	Breast Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.M617K	SIDM01681	Non-Cancerous	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.M617K	SIDM00760	Small Cell Lung Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.M617K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.8062
p.P702S	SIDM00667	Other Sarcomas	GDSC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1389
p.P702S	ACH-002246	Sarcoma	CCLE	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1389
p.P702S	Hs633T	soft tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1389
p.R664Q	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.R664Q	ACH-000728	Leukemia	CCLE	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.S711G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation altering degron motif	0.6993
p.P701S	Hs633T	soft tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	709:713	Mutation rewiring degron network	0.1111
p.S669T	LCLC-97TM1	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.0556

Kaplan plot for EPB41L5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L5

UniProt ID: Q9HCM4

Entrez ID: 57669

Protein name: Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L5 in