DegronMD

Uniprot ID: Q9HCM4

Source protein: Band 4.1-like protein 5

Source gene: EPB41L5

Class: DEG_SPOP_SBC_1

Location: 709:713

E3 ligase: SPOP

DEGRON score: 0.6181

ASA_SCORE: 73.12

COIL: 0.8314

CONS_SCORE: 0.5339

DSS_SCORE: 0.2402

HELIX: 0.0362

FCONS_SCORE: 1.0375

RIG_SCORE: 0.7587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P702Q	TCGA-D3-A2JP	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.P702Q	DO47407	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.F705L	TCGA-DK-A6AW	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	0.2222
p.F705L	TCGA-EO-A22U	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.2222
p.F705L	DO48566	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.F705L	DO43755	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.A703G	DO230524	LUSC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1667
p.S712G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	0.6993
p.S712G	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.6993
p.P702S	SIDM00667	Other Sarcomas	GDSC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.P702S	ACH-002246	Sarcoma	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1389
p.P702S	Hs633T	soft_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.S711G	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.6993
p.P701S	Hs633T	soft_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons