DegronMD

Uniprot ID: Q9UGI9

Source protein: 5'-AMP-activated protein kinase subunit gamma-3

Source gene: PRKAG3

Class: DEG_SPOP_SBC_1

Location: 41:45

E3 ligase: SPOP

DEGRON score: 0.9578

ASA_SCORE: 77.6

COIL: 0.895

CONS_SCORE: 0.2348

DSS_SCORE: 0.5851

HELIX: 0.0788

FCONS_SCORE: 1.0264

RIG_SCORE: 0.6609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R48I	TCGA-AA-A00N	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.25
p.R48I	DO9876	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.25
p.I49L	TCGA-AP-A0LM	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.2222
p.I49L	DO43306	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.A55V	TCGA-DF-A2KU	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.0556
p.A55V	DO223286	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0556
p.R48K	TCGA-EE-A2GD	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	0.25
p.R48K	DO37603	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	0.25
p.F53V	DO8264	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1111
p.L35M	DO50458	KIRC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1667
p.W46R	DO23192	LINC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.R50H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	0.1944
p.R50H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	0.1944
p.R50H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1944
p.S36L	SIDM00562	Breast Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.1944
p.S36L	ACH-002163	Breast Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1944
p.G51R	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.1667
p.G51R	ACH-000886	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1667
p.G51R	NCI-H2009	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons