DegronMD

Uniprot ID: Q6ZNA4

Source protein: E3 ubiquitin-protein ligase Arkadia

Source gene: RNF111

Class: DEG_SPOP_SBC_1

Location: 428:432

E3 ligase: SPOP

DEGRON score: 0.9917

ASA_SCORE: 77

COIL: 0.9136

CONS_SCORE: 0.4631

DSS_SCORE: 0.6306

HELIX: 0.06

FCONS_SCORE: 1.0123

RIG_SCORE: 0.6159

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S419C	TCGA-4P-AA8J	HNSC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.0833
p.S419C	DO52027	HNSC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0833
p.S423F	TCGA-G2-A2EF	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1944
p.S423F	TCGA-XF-A8HE	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1944
p.S423F	DO49797	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1944
p.S423F	DO726	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1944
p.S441L	TCGA-G2-A2EF	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	0.0833
p.S441L	DO726	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0833
p.E439K	TCGA-T3-A92N	HNSC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.E439K	DO219073	HNSC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.S432I	DO229029	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.7341
p.S419P	DO35122	PACA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0833
p.T418A	SIDM02059	Colorectal Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.0556
p.S435T	SIDM00681	Colorectal Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.S435T	SIDM00183	Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.S435T	SIDM01641	Non-Cancerous	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.S435T	SIDM00929	Chondrosarcoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.S435T	SIDM01648	Non-Cancerous	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.S435T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.S435T	SIDM01640	Acute Myeloid Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	0.25
p.A428P	SIDM01577	Plasma Cell Myeloma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.6392
p.A428P	ACH-000889	Myeloma	CCLE	AVTSS	DEG_SPOP_SBC_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons