DegronMD - Q5TCY1(TTBK1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S432R	TCGA-85-6560	LUSC	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation blocking phosphorylation signal	0.5
p.S432R	DO26752	LUSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation blocking phosphorylation signal	0.5
p.D440N	TCGA-A2-A0CR	BRCA	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.2778
p.D440N	DO44163	BRCA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.2778
p.F930Y	TCGA-A5-A0G2	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.0833
p.F930Y	DO41235	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.0833
p.Q719K	TCGA-A5-A1OF	UCEC	TCGA	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.3056
p.Q719K	DO42568	UCEC	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.3056
p.N730D	TCGA-AX-A05Z	UCEC	TCGA	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.2778
p.N730D	DO40884	UCEC	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.2778
p.A1187T	TCGA-AX-A0J1	UCEC	TCGA	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.1389
p.A1187T	DO41199	UCEC	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.1389
p.R1104W	TCGA-AX-A2HD	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.1944
p.R1104W	DO232224	PBCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.1944
p.R1104W	DO42608	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1109:1113	Mutation rewiring degron network	0.1944
p.R453K	TCGA-BF-A1PU	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1944
p.R453K	DO50278	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1944
p.R447C	TCGA-BF-AAP1	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.719
p.R447C	DO219464	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.719
p.S1190R	TCGA-BP-5010	KIRC	TCGA	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.2222
p.S1190R	DO17751	KIRC	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.2222
p.G914E	TCGA-CG-4465	STAD	TCGA	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.25
p.G914E	DO38627	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.25
p.P442L	TCGA-CV-7568	HNSC	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.6471
p.P442L	DO14160	HNSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.6471
p.G731R	TCGA-D9-A6EC	SKCM	TCGA	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.25
p.G731R	DO50291	SKCM	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.25
p.G731R	SIDM00185	Melanoma	GDSC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.25
p.G731R	ACH-002152	Skin Cancer	CCLE	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.25
p.A723T	TCGA-DF-A2KU	UCEC	TCGA	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.7139
p.A723T	DO223286	UCEC	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.7139
p.R1191K	TCGA-EE-A29E	SKCM	TCGA	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.25
p.R1191K	DO37831	SKCM	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.25
p.P445T	TCGA-EE-A29M	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7031
p.P445T	TCGA-EE-A2GK	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7031
p.P445T	DO37738	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7031
p.P445T	DO37404	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7031
p.E458D	TCGA-EK-A3GJ	CESC	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0556
p.E458D	DO49962	CESC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0556
p.P724L	TCGA-FW-A3R5	SKCM	TCGA	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.6471
p.P724L	DO37406	SKCM	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.6471
p.E734K	TCGA-FW-A3R5	SKCM	TCGA	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.1667
p.E734K	DO37406	SKCM	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.1667
p.S448F	TCGA-QG-A5Z1	COAD	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7982
p.S448F	DO51731	COAD	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7982
p.P434S	TCGA-WE-A8K4	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1111
p.P434S	DO51281	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1111
p.L1184S	DO48434	BLCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO48461	BLCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO222849	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO229016	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO229003	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO229005	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO230659	LAML	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.L1184S	DO228941	LICA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.0556
p.R436C	DO233709	GACA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.R447H	DO233913	GACA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation altering degron motif	0.7133
p.S1232N	DO15870	HNSC	ICGC	PASTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.6667
p.P457L	DO52029	HNSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0833
p.P457L	SIDM01261	Breast Carcinoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0833
p.P457L	SIDM00314	Breast Carcinoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0833
p.P457L	YMB-1-E	breast	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.0833
p.Q726H	DO229029	LICA	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.647
p.S921L	DO229054	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation altering degron motif	0.7667
p.G915D	DO229054	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.2778
p.R450L	DO229006	LICA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.2778
p.R450L	DO229008	LICA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.2778
p.N455S	DO230990	LUSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1389
p.N455S	DO224554	LUSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1389
p.E735K	DO220887	MELA	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.1389
p.P922S	DO222363	MELA	ICGC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.3056
p.R436H	DO224740	PACA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.R436H	SIDM00679	Cervical Carcinoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.R436H	HT-3	cervix	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1667
p.P718L	DO218856	SKCA	ICGC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation rewiring degron network	0.2778
p.S1110P	DO229264	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1109:1113	Mutation altering degron motif	0.5641
p.P1227H	DO229221	THCA	ICGC	PASTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0833
p.A1201D	DO229232	THCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	1194:1200	Mutation rewiring degron network	0.3056
p.P922L	SIDM01175	Other Sarcomas	GDSC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.3056
p.P922L	ACH-002309	Sarcoma	CCLE	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.3056
p.P922L	SW684	soft tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.3056
p.R1250W	SIDM00860	Head and Neck Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0556
p.R1250W	ACH-000846	Head and Neck Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0556
p.S1232I	SIDM00869	Non-Cancerous	GDSC	PASTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.6667
p.P727L	SIDM01106	Melanoma	GDSC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.7582
p.P727L	ACH-000822	Skin Cancer	CCLE	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.7582
p.P727L	SK-MEL-24	skin	COSMIC	VPLAPVQPQ	DEG_SIAH_1	720:728	Mutation altering degron motif	0.7582
p.P439Q	SIDM00003	Melanoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.25
p.P439Q	M14	skin	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.25
p.R1234C	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.V909A	ACH-000930	Breast Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.1111
p.V909A	HCC1569	breast	COSMIC	AVTSS	DEG_SPOP_SBC_1	917:921	Mutation rewiring degron network	0.1111
p.R435C	SNU-1040	large intestine	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	442:448	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTBK1

UniProt ID: Q5TCY1

Entrez ID: 84630

Protein name: Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TTBK1 in