DegronMD

Uniprot ID: Q5TCY1

Source protein: Tau-tubulin kinase 1

Source gene: TTBK1

Class: DEG_SCF_FBW7_1

Location: 1194:1200

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 79.9143

COIL: 0.8909

CONS_SCORE: 0.3433

DSS_SCORE: 0.6986

HELIX: 0.067

FCONS_SCORE: 1.0434

RIG_SCORE: 0.6255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1187T	TCGA-AX-A0J1	UCEC	TCGA	LQTPPGS	DEG_SCF_FBW7_1	0.1389
p.A1187T	DO41199	UCEC	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.1389
p.S1190R	TCGA-BP-5010	KIRC	TCGA	LQTPPGS	DEG_SCF_FBW7_1	0.2222
p.S1190R	DO17751	KIRC	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.2222
p.R1191K	TCGA-EE-A29E	SKCM	TCGA	LQTPPGS	DEG_SCF_FBW7_1	0.25
p.R1191K	DO37831	SKCM	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.25
p.L1184S	DO48434	BLCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO48461	BLCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO222849	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO229016	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO229003	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO229005	COCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO230659	LAML	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.L1184S	DO228941	LICA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.0556
p.A1201D	DO229232	THCA	ICGC	LQTPPGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCY1	Tau-tubulin kinase 1	DEG_SCF_FBW7_1	1194:1200	LQTPPGS	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons