DegronMD

Uniprot ID: Q5TCY1

Source protein: Tau-tubulin kinase 1

Source gene: TTBK1

Class: DEG_SCF_FBW7_1

Location: 442:448

E3 ligase: FBXW7

DEGRON score: 0.9868

ASA_SCORE: 94.9714

COIL: 0.9191

CONS_SCORE: 0.3875

DSS_SCORE: 0.6522

HELIX: 0.03

FCONS_SCORE: 1.0051

RIG_SCORE: 0.6601

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S432R	TCGA-85-6560	LUSC	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.5
p.S432R	DO26752	LUSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.5
p.D440N	TCGA-A2-A0CR	BRCA	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.2778
p.D440N	DO44163	BRCA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.2778
p.R453K	TCGA-BF-A1PU	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.1944
p.R453K	DO50278	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.1944
p.R447C	TCGA-BF-AAP1	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.719
p.R447C	DO219464	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.719
p.P442L	TCGA-CV-7568	HNSC	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.6471
p.P442L	DO14160	HNSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.6471
p.P445T	TCGA-EE-A29M	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.7031
p.P445T	TCGA-EE-A2GK	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.7031
p.P445T	DO37738	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.7031
p.P445T	DO37404	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.7031
p.E458D	TCGA-EK-A3GJ	CESC	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.0556
p.E458D	DO49962	CESC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.0556
p.S448F	TCGA-QG-A5Z1	COAD	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.7982
p.S448F	DO51731	COAD	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.7982
p.P434S	TCGA-WE-A8K4	SKCM	TCGA	PTTPVRS	DEG_SCF_FBW7_1	0.1111
p.P434S	DO51281	SKCM	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.1111
p.R436C	DO233709	GACA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.1667
p.R447H	DO233913	GACA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.7133
p.P457L	DO52029	HNSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.0833
p.P457L	SIDM01261	Breast Carcinoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	0.0833
p.P457L	SIDM00314	Breast Carcinoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	0.0833
p.P457L	YMB-1-E	breast	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	0.0833
p.R450L	DO229006	LICA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.2778
p.R450L	DO229008	LICA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.2778
p.N455S	DO230990	LUSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.1389
p.N455S	DO224554	LUSC	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.1389
p.R436H	DO224740	PACA	ICGC	PTTPVRS	DEG_SCF_FBW7_1	0.1667
p.R436H	SIDM00679	Cervical Carcinoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	0.1667
p.R436H	HT-3	cervix	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	0.1667
p.P439Q	SIDM00003	Melanoma	GDSC	PTTPVRS	DEG_SCF_FBW7_1	0.25
p.P439Q	M14	skin	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	0.25
p.R435C	SNU-1040	large_intestine	COSMIC	PTTPVRS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPVRS

Degron related mutations and impact score

Drug responses associated with TTBK1 mutations

All proteins holding degron of PTTPVRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCY1	Tau-tubulin kinase 1	DEG_SCF_FBW7_1	442:448	PTTPVRS	FBXW7	0.9868	More...