DegronMD

Uniprot ID: Q5TCY1

Source protein: Tau-tubulin kinase 1

Source gene: TTBK1

Class: DEG_SIAH_1

Location: 720:728

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8031

ASA_SCORE: 87.0556

COIL: 0.9409

CONS_SCORE: 0.3283

DSS_SCORE: 0.7279

HELIX: 0.0278

FCONS_SCORE: 0.8923

RIG_SCORE: 0.6586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q719K	TCGA-A5-A1OF	UCEC	TCGA	VPLAPVQPQ	DEG_SIAH_1	0.3056
p.Q719K	DO42568	UCEC	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.3056
p.N730D	TCGA-AX-A05Z	UCEC	TCGA	VPLAPVQPQ	DEG_SIAH_1	0.2778
p.N730D	DO40884	UCEC	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.2778
p.G731R	TCGA-D9-A6EC	SKCM	TCGA	VPLAPVQPQ	DEG_SIAH_1	0.25
p.G731R	DO50291	SKCM	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.25
p.G731R	SIDM00185	Melanoma	GDSC	VPLAPVQPQ	DEG_SIAH_1	0.25
p.G731R	ACH-002152	Skin Cancer	CCLE	VPLAPVQPQ	DEG_SIAH_1	0.25
p.A723T	TCGA-DF-A2KU	UCEC	TCGA	VPLAPVQPQ	DEG_SIAH_1	0.7139
p.A723T	DO223286	UCEC	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.7139
p.P724L	TCGA-FW-A3R5	SKCM	TCGA	VPLAPVQPQ	DEG_SIAH_1	0.6471
p.P724L	DO37406	SKCM	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.6471
p.E734K	TCGA-FW-A3R5	SKCM	TCGA	VPLAPVQPQ	DEG_SIAH_1	0.1667
p.E734K	DO37406	SKCM	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.1667
p.Q726H	DO229029	LICA	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.647
p.E735K	DO220887	MELA	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.1389
p.P718L	DO218856	SKCA	ICGC	VPLAPVQPQ	DEG_SIAH_1	0.2778
p.P727L	SIDM01106	Melanoma	GDSC	VPLAPVQPQ	DEG_SIAH_1	0.7582
p.P727L	ACH-000822	Skin Cancer	CCLE	VPLAPVQPQ	DEG_SIAH_1	0.7582
p.P727L	SK-MEL-24	skin	COSMIC	VPLAPVQPQ	DEG_SIAH_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCY1	Tau-tubulin kinase 1	DEG_SIAH_1	720:728	VPLAPVQPQ	SIAH1,SIAH2,SIAH3	0.8031	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons