DegronMD

Uniprot ID: Q5TCY1

Source protein: Tau-tubulin kinase 1

Source gene: TTBK1

Class: DEG_SPOP_SBC_1

Location: 917:921

E3 ligase: SPOP

DEGRON score: 0.9878

ASA_SCORE: 73.76

COIL: 0.914

CONS_SCORE: 0.3507

DSS_SCORE: 0.3726

HELIX: 0.0322

FCONS_SCORE: 1.0294

RIG_SCORE: 0.7773

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S921L	DO229054	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.7667
p.P922S	DO222363	MELA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.P922L	SIDM01175	Other Sarcomas	GDSC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.P922L	ACH-002309	Sarcoma	CCLE	AVTSS	DEG_SPOP_SBC_1	0.3056
p.P922L	SW684	soft_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.G915D	DO229054	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2778
p.G914E	TCGA-CG-4465	STAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.25
p.G914E	DO38627	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.25
p.V909A	ACH-000930	Breast Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1111
p.V909A	HCC1569	breast	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1111
p.F930Y	TCGA-A5-A0G2	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.0833
p.F930Y	DO41235	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...

Showing 1 to 10 of 10 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons