DegronMD - P15822(HIVEP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L662F	TCGA-06-5416	GBM	TCGA	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.0556
p.L662F	DO10880	GBM	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.0556
p.G778R	TCGA-17-Z057	LUAD	TCGA	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation rewiring degron network	0.1667
p.G725R	TCGA-18-4721	LUSC	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.G725R	DO27104	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.G725R	DO220902	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.V489I	TCGA-32-2494	GBM	TCGA	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.3056
p.V489I	DO11998	GBM	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.3056
p.R678H	TCGA-55-A4DG	LUAD	TCGA	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.3056
p.R678H	TCGA-CD-A4MG	STAD	TCGA	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.3056
p.R678H	DO26337	LUAD	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.3056
p.R678H	DO48009	STAD	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.3056
p.G725V	TCGA-66-2734	LUSC	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.G725V	DO26430	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.1389
p.S1408Y	TCGA-98-8021	LUSC	TCGA	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.0556
p.S1408Y	DO27468	LUSC	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.0556
p.T716M	TCGA-A5-A0G2	UCEC	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7423
p.T716M	TCGA-DU-6392	LGG	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7423
p.T716M	DO22237	LGG	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7423
p.T716M	DO41235	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7423
p.A728V	TCGA-A5-A0G2	UCEC	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.A728V	DO41235	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0556
p.T671M	TCGA-A5-A2K5	UCEC	TCGA	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation blocking phosphorylation signal	0.75
p.T671M	DO41379	UCEC	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation blocking phosphorylation signal	0.75
p.T671M	ACH-002396	Bone Cancer	CCLE	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation blocking phosphorylation signal	0.75
p.T671M	Sarc9371	bone	COSMIC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation blocking phosphorylation signal	0.75
p.L473V	TCGA-AA-A00N	COAD	TCGA	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.0556
p.L473V	DO9876	COAD	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.0556
p.R1285C	TCGA-AJ-A3EK	UCEC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.719
p.R1285C	DO41584	UCEC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.719
p.K1281N	TCGA-AK-3456	KIRC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.3056
p.K1281N	DO16910	KIRC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.3056
p.S1297R	TCGA-AP-A1DV	UCEC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.1389
p.S1297R	DO43186	UCEC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.1389
p.S791C	TCGA-B6-A0IJ	BRCA	TCGA	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation blocking phosphorylation signal	0.75
p.S791C	DO2813	BRCA	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation blocking phosphorylation signal	0.75
p.E1290Q	TCGA-BH-A0B6	BRCA	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.5633
p.E1290Q	DO2641	BRCA	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.5633
p.S340C	TCGA-BR-7704	STAD	TCGA	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1389
p.S340C	DO38360	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1389
p.D790Y	TCGA-BS-A0UV	UCEC	TCGA	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation altering degron motif	0.7325
p.D790Y	DO42793	UCEC	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation altering degron motif	0.7325
p.T2660M	TCGA-CX-A4AQ	HNSC	TCGA	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation altering degron motif	0.7423
p.T2660M	DO223265	HNSC	ICGC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation altering degron motif	0.7423
p.D672N	TCGA-D3-A51T	SKCM	TCGA	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation altering degron motif	0.6932
p.D672N	DO47389	SKCM	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation altering degron motif	0.6932
p.S492C	TCGA-D5-6932	COAD	TCGA	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation blocking phosphorylation signal	0.6667
p.S492C	DO9378	COAD	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation blocking phosphorylation signal	0.6667
p.D1389N	TCGA-DK-A6AW	BLCA	TCGA	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.2222
p.D1389N	DO48566	BLCA	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.2222
p.T715I	TCGA-EE-A2MI	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.5966
p.T715I	DO229446	SKCA	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.5966
p.T715I	DO37531	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.5966
p.S1387L	TCGA-EE-A3AA	SKCM	TCGA	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.1667
p.S1387L	DO222632	MELA	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.1667
p.S1387L	DO37571	SKCM	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.1667
p.R705M	TCGA-EE-A3AC	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0833
p.R705M	DO37631	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.0833
p.L1401R	TCGA-EO-A22R	UCEC	TCGA	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.25
p.L1401R	DO42713	UCEC	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.25
p.L1284I	TCGA-EO-A3KX	UCEC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.6063
p.L1284I	DO219774	UCEC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.6063
p.V325A	TCGA-FB-A5VM	PAAD	TCGA	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.V325A	DO49401	PAAD	ICGC	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.P339L	TCGA-FW-A3R5	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.P339L	DO37406	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.K481T	TCGA-QF-A5YS	UCEC	TCGA	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.2778
p.K481T	DO52426	UCEC	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.2778
p.P719S	TCGA-ZB-A966	THYM	TCGA	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.3056
p.T716A	DO228483	BRCA	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7139
p.T716A	DO230334	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7139
p.T716A	DO229005	COCA	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7139
p.T716A	DO52365	LUSC	ICGC	VTTST	DEG_SPOP_SBC_1	714:718	Mutation altering degron motif	0.7139
p.L1404V	DO8264	COAD	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.1667
p.L774P	DO233892	GACA	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation rewiring degron network	0.0556
p.A682S	DO228948	LICA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.1944
p.G493V	DO228952	LICA	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.1944
p.G493V	DO229027	LICA	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.1944
p.V686L	DO229027	LICA	ICGC	DSGYFS	DEG_SCF_TRCP1_1	672:677	Mutation rewiring degron network	0.0833
p.L1404F	DO229037	LICA	ICGC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation rewiring degron network	0.1667
p.E1288D	DO229045	LICA	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation altering degron motif	0.5647
p.P480R	DO230918	LUSC	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.25
p.P480R	DO224546	LUSC	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.25
p.D781H	DO220886	MELA	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation rewiring degron network	0.25
p.L473F	DO46372	OV	ICGC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.0556
p.G778E	DO46336	OV	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation rewiring degron network	0.1667
p.S1292F	DO49137	PACA	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.2778
p.P1396L	SIDM00969	Ovarian Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation altering degron motif	0.6471
p.P1396L	SIDM01117	Small Cell Lung Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation altering degron motif	0.6471
p.P1396L	SIDM00254	Neuroblastoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation altering degron motif	0.6471
p.P1396L	SIDM00875	Breast Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation altering degron motif	0.6471
p.P1396L	SIDM00954	Breast Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	1393:1398	Mutation altering degron motif	0.6471
p.D1299E	SIDM00950	Pancreatic Carcinoma	GDSC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.0833
p.D1299E	ACH-000243	Pancreatic Cancer	CCLE	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.0833
p.D1299E	DAN-G	pancreas	COSMIC	KRLRLAEIE	DEG_APCC_DBOX_1	1282:1290	Mutation rewiring degron network	0.0833
p.V334A	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.V334A	ACH-000021	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.V334A	NCI-H1693	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.I2653M	SIDM01019	Acute Myeloid Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.2222
p.I2653M	ACH-002258	Leukemia	CCLE	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.2222
p.I2653M	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.2222
p.G2655S	SIDM00867	Glioblastoma	GDSC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.2778
p.G2655S	ACH-000863	Brain Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.2778
p.G2655S	DBTRG-05MG	central nervous system	COSMIC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.2778
p.P783L	ACH-000695	Lung Cancer	CCLE	KSYIFKD	LIG_APCC_ABBAyCdc20_2	784:790	Mutation rewiring degron network	0.3056
p.A721V	ACH-000954	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	714:718	Mutation rewiring degron network	0.25
p.A320P	AMO-1	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.0833
p.G2654S	DBTRG-05MG	central nervous system	COSMIC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.25
p.I2652M	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	2657:2661	Mutation rewiring degron network	0.1944
p.R473Q	NCI-H1793	lung	COSMIC	LSIHSD	LIG_APCC_ABBA_1	483:488	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIVEP1

UniProt ID: P15822

Entrez ID: 3096

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HIVEP1 in