DegronMD

Uniprot ID: P15822

Source protein: Zinc finger protein 40

Source gene: HIVEP1

Class: DEG_SCF_FBW7_1

Location: 1393:1398

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 90.3167

COIL: 0.9407

CONS_SCORE: 0.2826

DSS_SCORE: 0.6031

HELIX: 0.0175

FCONS_SCORE: 0.8703

RIG_SCORE: 0.6613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1408Y	TCGA-98-8021	LUSC	TCGA	ITPPQT	DEG_SCF_FBW7_1	0.0556
p.S1408Y	DO27468	LUSC	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.0556
p.D1389N	TCGA-DK-A6AW	BLCA	TCGA	ITPPQT	DEG_SCF_FBW7_1	0.2222
p.D1389N	DO48566	BLCA	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.2222
p.S1387L	TCGA-EE-A3AA	SKCM	TCGA	ITPPQT	DEG_SCF_FBW7_1	0.1667
p.S1387L	DO222632	MELA	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.1667
p.S1387L	DO37571	SKCM	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.1667
p.L1401R	TCGA-EO-A22R	UCEC	TCGA	ITPPQT	DEG_SCF_FBW7_1	0.25
p.L1401R	DO42713	UCEC	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.25
p.L1404V	DO8264	COAD	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.1667
p.L1404F	DO229037	LICA	ICGC	ITPPQT	DEG_SCF_FBW7_1	0.1667
p.P1396L	SIDM00969	Ovarian Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	0.6471
p.P1396L	SIDM01117	Small Cell Lung Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	0.6471
p.P1396L	SIDM00254	Neuroblastoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	0.6471
p.P1396L	SIDM00875	Breast Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	0.6471
p.P1396L	SIDM00954	Breast Carcinoma	GDSC	ITPPQT	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SCF_FBW7_1	1393:1398	ITPPQT	FBXW7	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons