DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VTTST
Uniprot ID:
P15822
Source protein:
Zinc finger protein 40
Source gene:
HIVEP1
Class:
DEG_SPOP_SBC_1
Location:
714:718
E3 ligase:
SPOP
DEGRON score:
0.6604
ASA_SCORE:
93.32
COIL:
0.929
CONS_SCORE:
0.2512
DSS_SCORE:
0.6753
HELIX:
0.01
FCONS_SCORE:
0.9456
RIG_SCORE:
0.6761
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G725R
TCGA-18-4721
LUSC
TCGA
VTTST
DEG_SPOP_SBC_1
0.1389
p.G725R
DO27104
LUSC
ICGC
VTTST
DEG_SPOP_SBC_1
0.1389
p.G725R
DO220902
MELA
ICGC
VTTST
DEG_SPOP_SBC_1
0.1389
p.G725V
TCGA-66-2734
LUSC
TCGA
VTTST
DEG_SPOP_SBC_1
0.1389
p.G725V
DO26430
LUSC
ICGC
VTTST
DEG_SPOP_SBC_1
0.1389
p.T716M
TCGA-A5-A0G2
UCEC
TCGA
VTTST
DEG_SPOP_SBC_1
0.7423
p.T716M
TCGA-DU-6392
LGG
TCGA
VTTST
DEG_SPOP_SBC_1
0.7423
p.T716M
DO22237
LGG
ICGC
VTTST
DEG_SPOP_SBC_1
0.7423
p.T716M
DO41235
UCEC
ICGC
VTTST
DEG_SPOP_SBC_1
0.7423
p.A728V
TCGA-A5-A0G2
UCEC
TCGA
VTTST
DEG_SPOP_SBC_1
0.0556
p.A728V
DO41235
UCEC
ICGC
VTTST
DEG_SPOP_SBC_1
0.0556
p.T715I
TCGA-EE-A2MI
SKCM
TCGA
VTTST
DEG_SPOP_SBC_1
0.5966
p.T715I
DO229446
SKCA
ICGC
VTTST
DEG_SPOP_SBC_1
0.5966
p.T715I
DO37531
SKCM
ICGC
VTTST
DEG_SPOP_SBC_1
0.5966
p.R705M
TCGA-EE-A3AC
SKCM
TCGA
VTTST
DEG_SPOP_SBC_1
0.0833
p.R705M
DO37631
SKCM
ICGC
VTTST
DEG_SPOP_SBC_1
0.0833
p.P719S
TCGA-ZB-A966
THYM
TCGA
VTTST
DEG_SPOP_SBC_1
0.3056
p.T716A
DO228483
BRCA
ICGC
VTTST
DEG_SPOP_SBC_1
0.7139
p.T716A
DO230334
COCA
ICGC
VTTST
DEG_SPOP_SBC_1
0.7139
p.T716A
DO229005
COCA
ICGC
VTTST
DEG_SPOP_SBC_1
0.7139
p.T716A
DO52365
LUSC
ICGC
VTTST
DEG_SPOP_SBC_1
0.7139
p.A721V
ACH-000954
Endometrial/Uterine Cancer
CCLE
VTTST
DEG_SPOP_SBC_1
0.25
Drug responses associated with HIVEP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A5YKK6
CCR4-NOT transcription complex subunit 1
DEG_SPOP_SBC_1
1040:1044
VTTST
SPOP
0.9972
More...
O95274
Ly6/PLAUR domain-containing protein 3
DEG_SPOP_SBC_1
255:259
VTTST
SPOP
0.8718
More...
P08670
Vimentin
DEG_SPOP_SBC_1
31:35
VTTST
SPOP
0.9992
More...
P12270
Nucleoprotein TPR
DEG_SPOP_SBC_1
2244:2248
VTTST
SPOP
0.5533
More...
P15822
Zinc finger protein 40
DEG_SPOP_SBC_1
714:718
VTTST
SPOP
0.6604
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2256:2260
VTTST
SPOP
0.9908
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3362:3366
VTTST
SPOP
0.9176
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
4093:4097
VTTST
SPOP
0.9149
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
365:369
VTTST
SPOP
0.9781
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3430:3434
VTTST
SPOP
0.9177
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
4862:4866
VTTST
SPOP
0.9247
More...
Q99102
Mucin-4
DEG_SPOP_SBC_1
266:270
VTTST
SPOP
0.9076
More...
Q9H2Y7
Zinc finger protein 106
DEG_SPOP_SBC_1
1396:1400
VTTST
SPOP
0.9451
More...
Q9HAR2
Adhesion G protein-coupled receptor L3
DEG_SPOP_SBC_1
1372:1376
VTTST
SPOP
0.9817
More...
Q9ULV0
Unconventional myosin-Vb
DEG_SPOP_SBC_1
950:954
VTTST
SPOP
0.7192
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
1991:1995
VTTST
SPOP
0.8266
More...