DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VTTST
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
4093:4097
E3 ligase:
SPOP
DEGRON score:
0.9149
ASA_SCORE:
95.42
COIL:
0.9258
CONS_SCORE:
0.2671
DSS_SCORE:
0.6114
HELIX:
0.0158
FCONS_SCORE:
0.9775
RIG_SCORE:
0.7046
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T4089K
SIDM00401
Melanoma
GDSC
VTTST
DEG_SPOP_SBC_1
0.2222
p.Q4085K
SIDM01090
Colorectal Carcinoma
GDSC
VTTST
DEG_SPOP_SBC_1
0.1111
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A5YKK6
CCR4-NOT transcription complex subunit 1
DEG_SPOP_SBC_1
1040:1044
VTTST
SPOP
0.9972
More...
O95274
Ly6/PLAUR domain-containing protein 3
DEG_SPOP_SBC_1
255:259
VTTST
SPOP
0.8718
More...
P08670
Vimentin
DEG_SPOP_SBC_1
31:35
VTTST
SPOP
0.9992
More...
P12270
Nucleoprotein TPR
DEG_SPOP_SBC_1
2244:2248
VTTST
SPOP
0.5533
More...
P15822
Zinc finger protein 40
DEG_SPOP_SBC_1
714:718
VTTST
SPOP
0.6604
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2256:2260
VTTST
SPOP
0.9908
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3362:3366
VTTST
SPOP
0.9176
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
4093:4097
VTTST
SPOP
0.9149
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
365:369
VTTST
SPOP
0.9781
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3430:3434
VTTST
SPOP
0.9177
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
4862:4866
VTTST
SPOP
0.9247
More...
Q99102
Mucin-4
DEG_SPOP_SBC_1
266:270
VTTST
SPOP
0.9076
More...
Q9H2Y7
Zinc finger protein 106
DEG_SPOP_SBC_1
1396:1400
VTTST
SPOP
0.9451
More...
Q9HAR2
Adhesion G protein-coupled receptor L3
DEG_SPOP_SBC_1
1372:1376
VTTST
SPOP
0.9817
More...
Q9ULV0
Unconventional myosin-Vb
DEG_SPOP_SBC_1
950:954
VTTST
SPOP
0.7192
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
1991:1995
VTTST
SPOP
0.8266
More...