DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 365:369

E3 ligase: SPOP

DEGRON score: 0.9781

ASA_SCORE: 85.54

COIL: 0.8338

CONS_SCORE: 0.5236

DSS_SCORE: 0.5916

HELIX: 0.0134

FCONS_SCORE: 1

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S355L	TCGA-DK-A6B2	BLCA	TCGA	VTTST	DEG_SPOP_SBC_1	0.0556
p.S355L	DO48543	BLCA	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.E379K	TCGA-Q1-A73O	CESC	TCGA	VTTST	DEG_SPOP_SBC_1	0.0556
p.E379K	DO51612	CESC	ICGC	VTTST	DEG_SPOP_SBC_1	0.0556
p.A378T	DO11854	GBM	ICGC	VTTST	DEG_SPOP_SBC_1	0.0833
p.S373L	DO220891	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	0.2222
p.S373L	DO222837	MELA	ICGC	VTTST	DEG_SPOP_SBC_1	0.2222
p.L374F	SIDM00678	Bladder Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1944
p.L374F	SIDM01397	Melanoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.1944
p.S362C	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	0.25
p.S362C	ACH-000893	Lung Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.25
p.S362C	NCI-H1651	lung	COSMIC	VTTST	DEG_SPOP_SBC_1	0.25
p.P375T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VTTST	DEG_SPOP_SBC_1	0.1667
p.P375T	ACH-002059	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	0.1667
p.P375T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VTTST	DEG_SPOP_SBC_1	0.1667
p.T377I	ACH-001719	Ovarian Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.1111
p.T369S	ACH-001853	Bile Duct Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.6005
p.P371A	ACH-001853	Bile Duct Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1040:1044	VTTST	SPOP	0.9972	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	255:259	VTTST	SPOP	0.8718	More...
P08670	Vimentin	DEG_SPOP_SBC_1	31:35	VTTST	SPOP	0.9992	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2244:2248	VTTST	SPOP	0.5533	More...
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	714:718	VTTST	SPOP	0.6604	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2256:2260	VTTST	SPOP	0.9908	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3362:3366	VTTST	SPOP	0.9176	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4093:4097	VTTST	SPOP	0.9149	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	365:369	VTTST	SPOP	0.9781	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3430:3434	VTTST	SPOP	0.9177	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	4862:4866	VTTST	SPOP	0.9247	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	266:270	VTTST	SPOP	0.9076	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1396:1400	VTTST	SPOP	0.9451	More...
Q9HAR2	Adhesion G protein-coupled receptor L3	DEG_SPOP_SBC_1	1372:1376	VTTST	SPOP	0.9817	More...
Q9ULV0	Unconventional myosin-Vb	DEG_SPOP_SBC_1	950:954	VTTST	SPOP	0.7192	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1991:1995	VTTST	SPOP	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons