DegronMD - O95274(LYPD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P243H	TCGA-B5-A3FC	UCEC	TCGA	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P243H	DO41871	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.T256I	TCGA-D6-6515	HNSC	TCGA	VTTST	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.5966
p.T256I	DO14206	HNSC	ICGC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.5966
p.T256I	DO42673	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.5966
p.S251L	TCGA-DR-A0ZM	CESC	TCGA	VASTT	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7667
p.S251L	DO6254	CESC	ICGC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7667
p.P243S	TCGA-EB-A5UN	SKCM	TCGA	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P243S	DO47267	SKCM	ICGC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.K270N	DO228751	EOPC	ICGC	PTSTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.3056
p.T247M	DO234312	ESAD	ICGC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247M	DO234312	ESAD	ICGC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.A250D	DO228948	LICA	ICGC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.6682
p.S260L	SIDM02022	Colorectal Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S260L	SIDM02022	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.3056
p.S260L	SIDM02022	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1944
p.T247K	SIDM00773	Non-Cancerous	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00773	Non-Cancerous	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00654	Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00654	Small Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00690	Head and Neck Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00690	Head and Neck Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00878	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00878	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00971	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00971	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00309	Mesothelioma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00309	Mesothelioma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM01159	Other Sarcomas	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM01159	Other Sarcomas	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00793	Burkitt's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00793	Burkitt's Lymphoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00954	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00954	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00808	Burkitt's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00808	Burkitt's Lymphoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM00628	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM00628	Breast Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.T247K	SIDM01254	Burkitt's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.T247K	SIDM01254	Burkitt's Lymphoma	GDSC	VTTST	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1111
p.R240Q	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R240Q	ACH-002264	Esophageal Cancer	CCLE	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R240Q	KYSE-50	oesophagus	COSMIC	VASTT	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.T268N	SIDM01504	Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.7055
p.T268N	ACH-000594	Lung Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.7055
p.A274T	ACH-001377	Pancreatic Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LYPD3

UniProt ID: O95274

Entrez ID: 27076

Protein name: Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LYPD3 in