DegronMD

Uniprot ID: O95274

Source protein: Ly6/PLAUR domain-containing protein 3

Source gene: LYPD3

Class: DEG_SPOP_SBC_1

Location: 249:253

E3 ligase: SPOP

DEGRON score: 0.9553

ASA_SCORE: 95.92

COIL: 0.9452

CONS_SCORE: 0.4865

DSS_SCORE: 0.6665

HELIX: 0.0274

FCONS_SCORE: 0.6601

RIG_SCORE: 0.6687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P243H	TCGA-B5-A3FC	UCEC	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.P243H	DO41871	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.S251L	TCGA-DR-A0ZM	CESC	TCGA	VASTT	DEG_SPOP_SBC_1	0.7667
p.S251L	DO6254	CESC	ICGC	VASTT	DEG_SPOP_SBC_1	0.7667
p.P243S	TCGA-EB-A5UN	SKCM	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.P243S	DO47267	SKCM	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.T247M	DO234312	ESAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.2778
p.A250D	DO228948	LICA	ICGC	VASTT	DEG_SPOP_SBC_1	0.6682
p.S260L	SIDM02022	Colorectal Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.T247K	SIDM00773	Non-Cancerous	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00654	Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00690	Head and Neck Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00878	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00971	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00309	Mesothelioma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM01159	Other Sarcomas	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00793	Burkitt's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00954	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00808	Burkitt's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM00628	Breast Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.T247K	SIDM01254	Burkitt's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.R240Q	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.0833
p.R240Q	ACH-002264	Esophageal Cancer	CCLE	VASTT	DEG_SPOP_SBC_1	0.0833
p.R240Q	KYSE-50	oesophagus	COSMIC	VASTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15083	ERC protein 2	DEG_SPOP_SBC_1	70:74	VASTT	SPOP	0.9875	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	249:253	VASTT	SPOP	0.9553	More...
P15144	Aminopeptidase N	DEG_SPOP_SBC_1	46:50	VASTT	SPOP	0.7621	More...
Q14CZ8	Hepatocyte cell adhesion molecule	DEG_SPOP_SBC_1	152:156	VASTT	SPOP	0.6335	More...
Q86V86	Serine/threonine-protein kinase pim-3	DEG_SPOP_SBC_1	316:320	VASTT	SPOP	0.7149	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	478:482	VASTT	SPOP	0.6062	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	129:133	VASTT	SPOP	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VASTT

Degron related mutations and impact score

Drug responses associated with LYPD3 mutations

All proteins holding degron of VASTT