DegronMD

Uniprot ID: Q14CZ8

Source protein: Hepatocyte cell adhesion molecule

Source gene: HEPACAM

Class: DEG_SPOP_SBC_1

Location: 152:156

E3 ligase: SPOP

DEGRON score: 0.6335

ASA_SCORE: 62.12

COIL: 0.5814

CONS_SCORE: 0.5055

DSS_SCORE: 0.1898

HELIX: 0.0164

FCONS_SCORE: 0.7861

RIG_SCORE: 0.8632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E162K	TCGA-A5-A0G2	UCEC	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.E162K	DO41235	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.S146L	TCGA-AA-A010	COAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.S146L	TCGA-AZ-4315	COAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.S146L	TCGA-BR-8680	STAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.S146L	DO8842	COAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.S146L	DO47769	STAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.Q149R	TCGA-AD-5900	COAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.25
p.Q149R	DO8514	COAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.25
p.S161R	TCGA-HU-A4GH	STAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.1944
p.S161R	DO47743	STAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15083	ERC protein 2	DEG_SPOP_SBC_1	70:74	VASTT	SPOP	0.9875	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	249:253	VASTT	SPOP	0.9553	More...
P15144	Aminopeptidase N	DEG_SPOP_SBC_1	46:50	VASTT	SPOP	0.7621	More...
Q14CZ8	Hepatocyte cell adhesion molecule	DEG_SPOP_SBC_1	152:156	VASTT	SPOP	0.6335	More...
Q86V86	Serine/threonine-protein kinase pim-3	DEG_SPOP_SBC_1	316:320	VASTT	SPOP	0.7149	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	478:482	VASTT	SPOP	0.6062	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	129:133	VASTT	SPOP	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons