DegronMD

Uniprot ID: Q9Y467

Source protein: Sal-like protein 2

Source gene: SALL2

Class: DEG_SPOP_SBC_1

Location: 478:482

E3 ligase: SPOP

DEGRON score: 0.6062

ASA_SCORE: 65.4

COIL: 0.6526

CONS_SCORE: 0.3751

DSS_SCORE: 0.4762

HELIX: 0.0352

FCONS_SCORE: 0.9002

RIG_SCORE: 0.7698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R474H	TCGA-A6-5665	COAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.2222
p.R474H	SIDM00059	Ovarian Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.2222
p.S488L	DO51867	BLCA	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.A469V	DO8730	COAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.0833
p.A469V	DO41871	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.0833
p.A469V	DO42568	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.0833
p.A477V	DO43274	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.S489G	SIDM01112	Osteosarcoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.S489G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.S489G	SIDM00721	Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.S489G	SIDM01140	Ovarian Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.S489G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.S489G	SIDM01752	Pancreatic Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1389
p.T479A	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	VASTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15083	ERC protein 2	DEG_SPOP_SBC_1	70:74	VASTT	SPOP	0.9875	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	249:253	VASTT	SPOP	0.9553	More...
P15144	Aminopeptidase N	DEG_SPOP_SBC_1	46:50	VASTT	SPOP	0.7621	More...
Q14CZ8	Hepatocyte cell adhesion molecule	DEG_SPOP_SBC_1	152:156	VASTT	SPOP	0.6335	More...
Q86V86	Serine/threonine-protein kinase pim-3	DEG_SPOP_SBC_1	316:320	VASTT	SPOP	0.7149	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	478:482	VASTT	SPOP	0.6062	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	129:133	VASTT	SPOP	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons