DegronMD - Q9Y467(SALL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S534L	TCGA-05-4424	LUAD	TCGA	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1667
p.R547C	TCGA-19-5956	GBM	TCGA	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation altering degron motif	0.8301
p.S873L	TCGA-4Z-AA7Y	BLCA	TCGA	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.1667
p.S625L	TCGA-4Z-AA7Y	BLCA	TCGA	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1389
p.S259Y	TCGA-4Z-AA7Y	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.8231
p.S259Y	DO51867	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.8231
p.R294Q	TCGA-58-8387	LUSC	TCGA	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.R294Q	TCGA-AZ-6598	COAD	TCGA	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.R294Q	TCGA-B5-A11Y	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.R294Q	TCGA-CV-A6JZ	HNSC	TCGA	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.R294Q	TCGA-R6-A6KZ	ESCA	TCGA	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.P881R	TCGA-66-2765	LUSC	TCGA	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation altering degron motif	0.7512
p.D442H	TCGA-92-8065	LUSC	TCGA	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2778
p.A606V	TCGA-A5-A1OF	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1111
p.A606V	TCGA-AA-3977	COAD	TCGA	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1111
p.A606V	TCGA-B5-A3FC	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1111
p.R474H	TCGA-A6-5665	COAD	TCGA	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2222
p.R474H	SIDM00059	Ovarian Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.2222
p.P869L	TCGA-A6-6649	COAD	TCGA	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.0556
p.P869L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.0556
p.P869L	ACH-000665	Lung Cancer	CCLE	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.0556
p.P869L	SK-MES-1	lung	COSMIC	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.0556
p.V456M	TCGA-AP-A059	UCEC	TCGA	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.S256Y	TCGA-B5-A1MR	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6009
p.S256Y	DO41758	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.6009
p.G883V	TCGA-BQ-7056	KIRP	TCGA	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation altering degron motif	0.6421
p.L890S	TCGA-CK-6746	COAD	TCGA	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.1667
p.S455Y	TCGA-CN-4738	HNSC	TCGA	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1389
p.A614V	TCGA-D1-A15X	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.5825
p.V539M	TCGA-D7-5578	STAD	TCGA	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.1389
p.V539M	TCGA-D7-5578	STAD	TCGA	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.3056
p.V444L	TCGA-E7-A541	BLCA	TCGA	VITSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.6765
p.P434L	TCGA-EE-A3J5	SKCM	TCGA	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.G533D	TCGA-FW-A3R5	SKCM	TCGA	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1389
p.G533S	TCGA-FW-A3R5	SKCM	TCGA	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1389
p.P302L	TCGA-FW-A3R5	SKCM	TCGA	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation altering degron motif	0.6471
p.S551I	TCGA-VQ-AA6A	STAD	TCGA	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation altering degron motif	0.623
p.E892Q	TCGA-XF-A8HH	BLCA	TCGA	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.1111
p.T564I	DO51867	BLCA	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.0556
p.S488L	DO51867	BLCA	ICGC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1667
p.V307L	DO44037	BLCA	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.A546T	DO219050	BLCA	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation altering degron motif	0.7139
p.P892S	DO219002	BLCA	ICGC	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.1111
p.Y264C	DO488	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.1944
p.P291T	DO223732	CESC	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.1389
p.R256C	DO10694	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.8301
p.R256C	DO220110	SARC	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.8301
p.F563L	DO7783	COAD	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.0833
p.A469V	DO8730	COAD	ICGC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0833
p.A469V	DO41871	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0833
p.A469V	DO42568	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.0833
p.G609R	DO230334	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO229013	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO229016	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO229003	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO229005	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO234285	ESAD	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO50989	LAML	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO230556	LUSC	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO52365	LUSC	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.G609R	DO231067	LUSC	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.E451G	DO50319	ESAD	ICGC	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.25
p.T259M	DO234233	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation altering degron motif	0.7423
p.N296S	DO233258	GACA	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2778
p.T564A	DO233767	GACA	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.0556
p.A885V	DO233764	GACA	ICGC	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.3056
p.G607R	DO51553	KIRP	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1389
p.G607R	DO51246	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1389
p.S310C	DO228380	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.1389
p.P297Q	DO228952	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.3056
p.D305E	DO229025	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2778
p.T452K	DO229025	LICA	ICGC	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2222
p.T309N	DO229008	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.1667
p.K289R	DO23314	LINC	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.0833
p.E623G	DO23678	LUAD	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.D305H	DO27074	LUSC	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2778
p.P894S	DO222632	MELA	ICGC	LTPEGE	DEG_SCF_FBW7_2	879:884	Mutation rewiring degron network	0.0556
p.G609V	DO37511	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.P612H	DO37507	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.2778
p.P297L	DO47331	SKCM	ICGC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.3056
p.K562R	DO47801	STAD	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.1111
p.I253T	DO40884	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation blocking phosphorylation signal	0.7222
p.R538H	DO40978	UCEC	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.1111
p.R538H	DO40978	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.2778
p.R538H	DND-41	haematopoietic and lymphoid tissue	COSMIC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.1111
p.R538H	DND-41	haematopoietic and lymphoid tissue	COSMIC	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.2778
p.A477V	DO43274	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.3056
p.S555F	DO41572	UCEC	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.3056
p.F245C	DO41488	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.0556
p.R547H	SIDM00455	Pancreatic Carcinoma	GDSC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation altering degron motif	0.8244
p.R547H	ACH-000599	Pancreatic Cancer	CCLE	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation altering degron motif	0.8244
p.R547H	PA-TU-8902	pancreas	COSMIC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation altering degron motif	0.8244
p.L563P	SIDM00330	Neuroblastoma	GDSC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.0833
p.L563P	ACH-001355	Neuroblastoma	CCLE	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.0833
p.L563P	LAN-6	autonomic ganglia	COSMIC	TRMQLSKLV	DEG_APCC_DBOX_1	546:554	Mutation rewiring degron network	0.0833
p.S489G	SIDM01112	Osteosarcoma	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.S489G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.S489G	SIDM00721	Small Cell Lung Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.S489G	SIDM01140	Ovarian Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.S489G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.S489G	SIDM01752	Pancreatic Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation rewiring degron network	0.1389
p.G530E	SIDM00619	Thyroid Gland Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.0556
p.G530E	SIDM01471	Chronic Myelogenous Leukemia	GDSC	AESST	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.0556
p.V292L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.1667
p.V292L	ACH-000929	Lung Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.1667
p.V292L	NCI-H2110	lung	COSMIC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.1667
p.T616I	SIDM00841	Colorectal Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.8189
p.T616A	SIDM00907	Burkitt's Lymphoma	GDSC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.825
p.T616A	CA46	haematopoietic and lymphoid tissue	COSMIC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.825
p.Y443C	SIDM00537	Colorectal Carcinoma	GDSC	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.Y443C	ACH-000982	Colon/Colorectal Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.Y443C	ACH-001345	Colon/Colorectal Cancer	CCLE	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.Y443C	GP5d	large intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.P307S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.P307S	ACH-000964	Leukemia	CCLE	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.2222
p.P304S	ACH-002287	Colon/Colorectal Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.3056
p.P621L	HCC1569	breast	COSMIC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.25
p.E623K	SW684	soft tissue	COSMIC	APTTS	DEG_SPOP_SBC_1	614:618	Mutation blocking phosphorylation signal	0.6389
p.H254Y	SNU-1040	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	255:259	Mutation rewiring degron network	0.3056
p.P439S	MCC13	skin	COSMIC	VITSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1944
p.T479A	CA46	haematopoietic and lymphoid tissue	COSMIC	VASTT	DEG_SPOP_SBC_1	478:482	Mutation altering degron motif	0.7139
p.P444S	CW-2	large intestine	COSMIC	VITSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.6752
p.Y306C	GP5d	large intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	298:303	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SALL2

UniProt ID: Q9Y467

Entrez ID: 6297

Protein name: Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SALL2 in