DegronMD

Uniprot ID: Q9Y467

Source protein: Sal-like protein 2

Source gene: SALL2

Class: DEG_SPOP_SBC_1

Location: 540:544

E3 ligase: SPOP

DEGRON score: 0.9672

ASA_SCORE: 74.2

COIL: 0.5476

CONS_SCORE: 0.3545

DSS_SCORE: 0.4473

HELIX: 0.0216

FCONS_SCORE: 0.8928

RIG_SCORE: 0.6915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S534L	TCGA-05-4424	LUAD	TCGA	AESST	DEG_SPOP_SBC_1	0.1667
p.V539M	TCGA-D7-5578	STAD	TCGA	AESST	DEG_SPOP_SBC_1	0.3056
p.G533D	TCGA-FW-A3R5	SKCM	TCGA	AESST	DEG_SPOP_SBC_1	0.1389
p.G533S	TCGA-FW-A3R5	SKCM	TCGA	AESST	DEG_SPOP_SBC_1	0.1389
p.R538H	DO40978	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	0.2778
p.R538H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AESST	DEG_SPOP_SBC_1	0.2778
p.G530E	SIDM00619	Thyroid Gland Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.0556
p.G530E	SIDM01471	Chronic Myelogenous Leukemia	GDSC	AESST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2137:2141	AESST	SPOP	0.9956	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1244:1248	AESST	SPOP	0.7953	More...
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_SPOP_SBC_1	223:227	AESST	SPOP	0.9846	More...
Q96QE2	Proton myo-inositol cotransporter	DEG_SPOP_SBC_1	45:49	AESST	SPOP	0.5879	More...
Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	DEG_SPOP_SBC_1	60:64	AESST	SPOP	0.8136	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	540:544	AESST	SPOP	0.9672	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	386:390	AESST	SPOP	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons