DegronMD - O15018(PDZD2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A2177P	TCGA-12-0778	GBM	TCGA	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1944
p.A2177P	DO11411	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1944
p.C2022Y	TCGA-13-0905	OV	TCGA	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.0556
p.C2022Y	DO31490	OV	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.0556
p.G1576S	TCGA-22-4593	LUSC	TCGA	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.G1576S	TCGA-22-4593	LUSC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1389
p.G1576S	DO27018	LUSC	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.G1576S	DO27018	LUSC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1389
p.G1576S	DO222504	MELA	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.G1576S	DO222504	MELA	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1389
p.G1576S	SIDM00781	Colorectal Carcinoma	GDSC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.G1576S	SIDM00781	Colorectal Carcinoma	GDSC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1389
p.G1576S	SIDM00780	Colorectal Carcinoma	GDSC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.G1576S	SIDM00780	Colorectal Carcinoma	GDSC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1389
p.G1576S	SNU-C2B	large intestine	COSMIC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.G1576S	SNU-C2B	large intestine	COSMIC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1389
p.R1583C	TCGA-2W-A8YY	CESC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.8301
p.R1583C	TCGA-EO-A22U	UCEC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.8301
p.R1583C	DO223732	CESC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.8301
p.R1583C	DO232952	PEME	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.8301
p.R1583C	DO43755	UCEC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.8301
p.P693Q	TCGA-55-6979	LUAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.P693Q	DO24110	LUAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.P295S	TCGA-56-7222	LUSC	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.P295S	DO26842	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.K2463R	TCGA-56-8626	LUSC	TCGA	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation substituting flanking lysine	0.2778
p.K2463R	DO45506	LUSC	ICGC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation substituting flanking lysine	0.2778
p.M2421I	TCGA-58-8393	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.0556
p.M2421I	DO45498	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.0556
p.P905L	TCGA-A5-A0G2	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation altering degron motif	0.6471
p.P905L	DO41235	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation altering degron motif	0.6471
p.H910R	TCGA-A5-A0G2	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2778
p.H910R	DO41235	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2778
p.A2507T	TCGA-AA-3815	COAD	TCGA	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1389
p.A2507T	TCGA-E6-A2P9	UCEC	TCGA	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1389
p.A2507T	DO9924	COAD	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1389
p.A2507T	DO43714	UCEC	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1389
p.T297A	TCGA-AA-A00N	COAD	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.25
p.T297A	DO9876	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.25
p.H2143N	TCGA-AA-A010	COAD	TCGA	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation rewiring degron network	0.2778
p.E2513K	TCGA-AC-A23H	BRCA	TCGA	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.3056
p.E2513K	DO2401	BRCA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.3056
p.A210V	TCGA-AG-A002	READ	TCGA	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	TCGA-BB-7870	HNSC	TCGA	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	TCGA-HU-A4H8	STAD	TCGA	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	DO14378	HNSC	ICGC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	DO47869	STAD	ICGC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	ACH-000693	Esophageal Cancer	CCLE	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.A210V	KYSE-180	oesophagus	COSMIC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.S682L	TCGA-AJ-A3EK	UCEC	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.6556
p.S682L	TCGA-HU-8602	STAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.6556
p.S682L	DO47829	STAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.6556
p.S682L	DO41584	UCEC	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.6556
p.T1305I	TCGA-AP-A059	UCEC	TCGA	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.25
p.T1305I	DO41361	UCEC	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.25
p.D2494G	TCGA-AP-A0LM	UCEC	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.1111
p.D2494G	DO43306	UCEC	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.1111
p.P2282S	TCGA-AX-A06F	UCEC	TCGA	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.6752
p.P2282S	DO41752	UCEC	ICGC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.6752
p.P2282S	SIDM00216	Colorectal Carcinoma	GDSC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.6752
p.P2282S	ACH-000989	Colon/Colorectal Cancer	CCLE	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.6752
p.P2282S	SNU-175	large intestine	COSMIC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.6752
p.V2508M	TCGA-AX-A1C7	UCEC	TCGA	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1667
p.V2508M	DO41115	UCEC	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1667
p.A1297V	TCGA-AX-A1CE	UCEC	TCGA	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.A1297V	TCGA-FI-A2D5	UCEC	TCGA	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.A1297V	TCGA-WS-AB45	COAD	TCGA	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.A1297V	DO51734	COAD	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.A1297V	DO232761	PBCA	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.A1297V	DO42280	UCEC	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.A1297V	DO41331	UCEC	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2778
p.N2289S	TCGA-AX-A1CE	UCEC	TCGA	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.1389
p.N2289S	DO42280	UCEC	ICGC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.1389
p.N2289S	SIDM00878	Breast Carcinoma	GDSC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.1389
p.N2289S	ACH-000930	Breast Cancer	CCLE	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.1389
p.N2289S	HCC1569	breast	COSMIC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.1389
p.R1581C	TCGA-BH-A0AY	BRCA	TCGA	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.25
p.R1581C	TCGA-BH-A0AY	BRCA	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.2778
p.R1581C	DO5025	BRCA	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.25
p.R1581C	DO5025	BRCA	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.2778
p.R1306Q	TCGA-BH-A0B6	BRCA	TCGA	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2222
p.R1306Q	DO2641	BRCA	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2222
p.E2432Q	TCGA-BH-A0W7	BRCA	TCGA	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation altering degron motif	0.5633
p.E2432Q	DO1272	BRCA	ICGC	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation altering degron motif	0.5633
p.R2023K	TCGA-BH-A2L8	BRCA	TCGA	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.0833
p.R2023K	DO44242	BRCA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.0833
p.A1296E	TCGA-BJ-A0Z9	THCA	TCGA	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.25
p.A1296E	DO39441	THCA	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.25
p.A691T	TCGA-BR-8081	STAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1111
p.A691T	DO51478	PACA	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1111
p.A691T	DO38795	STAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1111
p.K1588N	TCGA-BR-8361	STAD	TCGA	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation altering degron motif	0.5806
p.K1588N	TCGA-BR-8361	STAD	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.5806
p.K1588N	DO48032	STAD	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation altering degron motif	0.5806
p.K1588N	DO48032	STAD	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.5806
p.R2427W	TCGA-CA-6717	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.2222
p.R2427W	DO8264	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.2222
p.S2440L	TCGA-CA-6717	COAD	TCGA	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation blocking phosphorylation signal	0.6389
p.S2440L	DO8264	COAD	ICGC	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation blocking phosphorylation signal	0.6389
p.R308C	TCGA-CG-4442	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2222
p.R308C	TCGA-P3-A6SW	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2222
p.R308C	DO227668	COCA	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2222
p.R308C	DO49062	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2222
p.R308C	DO38380	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2222
p.S2173P	TCGA-CG-5723	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.3056
p.S2173P	DO38376	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.3056
p.D298N	TCGA-CN-4739	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2778
p.D298N	DO14478	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2778
p.D298A	TCGA-CN-4739	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2778
p.D298A	DO14478	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2778
p.S2475L	TCGA-D1-A103	UCEC	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation blocking phosphorylation signal	0.6944
p.S2475L	DO42312	UCEC	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation blocking phosphorylation signal	0.6944
p.P693L	TCGA-D1-A2G0	UCEC	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.P693L	TCGA-QG-A5YX	COAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.P693L	DO44093	COAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.P693L	DO43049	UCEC	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.G213R	TCGA-D3-A8GQ	SKCM	TCGA	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.0833
p.G213R	DO51246	SKCM	ICGC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.0833
p.E2260K	TCGA-D3-A8GV	SKCM	TCGA	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation altering degron motif	0.7022
p.E2260K	DO219477	SKCM	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation altering degron motif	0.7022
p.T302N	TCGA-D7-6526	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.7055
p.T302N	DO38803	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.7055
p.E2025Q	TCGA-DK-AA74	BLCA	TCGA	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.1389
p.E2025Q	DO219011	BLCA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.1389
p.L2493I	TCGA-DU-6392	LGG	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.1389
p.L2493I	DO22237	LGG	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.1389
p.T2141A	TCGA-DU-7298	LGG	TCGA	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation altering degron motif	0.7139
p.T2141A	DO22679	LGG	ICGC	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation altering degron motif	0.7139
p.S2530L	TCGA-E6-A1LX	UCEC	TCGA	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation blocking phosphorylation signal	0.5278
p.S2530L	DO41020	UCEC	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation blocking phosphorylation signal	0.5278
p.P680R	TCGA-E8-A417	THCA	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.7512
p.P680R	DO38898	THCA	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.7512
p.T2472M	TCGA-EA-A3HS	CESC	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation blocking phosphorylation signal	0.6111
p.T2472M	DO6260	CESC	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation blocking phosphorylation signal	0.6111
p.P2269L	TCGA-EB-A553	SKCM	TCGA	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation altering degron motif	0.6471
p.P2269L	DO47329	SKCM	ICGC	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation altering degron motif	0.6471
p.D1575N	TCGA-EE-A20C	SKCM	TCGA	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.0833
p.D1575N	TCGA-EE-A20C	SKCM	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1111
p.D1575N	DO222775	MELA	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.0833
p.D1575N	DO222775	MELA	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1111
p.D1575N	DO47665	SKCM	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.0833
p.D1575N	DO47665	SKCM	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1111
p.G2450R	TCGA-EE-A2GM	SKCM	TCGA	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.3056
p.G2450R	DO37555	SKCM	ICGC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.3056
p.S675I	TCGA-EE-A2GN	SKCM	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.3056
p.S675I	DO37896	SKCM	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.3056
p.P2430T	TCGA-EE-A2GN	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.3056
p.P2430T	DO37896	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.3056
p.P693T	TCGA-EE-A2ME	SKCM	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.P693T	DO38011	SKCM	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0556
p.S311L	TCGA-EE-A2MM	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1389
p.S311L	DO222678	MELA	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1389
p.S311L	DO37770	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1389
p.P680L	TCGA-ER-A19L	SKCM	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.7582
p.P680L	DO37587	SKCM	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.7582
p.M2456I	TCGA-EW-A1PH	BRCA	TCGA	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation altering degron motif	0.6507
p.M2456I	DO2551	BRCA	ICGC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation altering degron motif	0.6507
p.E912K	TCGA-FR-A8YC	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2222
p.E912K	DO50301	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2222
p.G313C	TCGA-FY-A40L	THCA	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.0833
p.G313C	DO39028	THCA	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.0833
p.E2484K	TCGA-GC-A3OO	BLCA	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation altering degron motif	0.591
p.E2484K	DO518	BLCA	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation altering degron motif	0.591
p.P295L	TCGA-GN-A269	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.P295L	DO37483	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.K2511E	TCGA-HU-A4GU	STAD	TCGA	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation substituting flanking lysine	0.3611
p.K2511E	DO47849	STAD	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation substituting flanking lysine	0.3611
p.V2477M	TCGA-IG-A5S3	ESCA	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.3056
p.T668M	TCGA-L5-A891	ESCA	TCGA	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1111
p.R208Q	TCGA-LN-A9FP	ESCA	TCGA	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.2222
p.R208Q	SIDM00545	Melanoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.2222
p.A2177T	TCGA-VQ-A91K	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1944
p.A2177T	DO51785	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1944
p.A854E	TCGA-VR-A8EQ	ESCA	TCGA	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.2222
p.E1597Q	TCGA-VS-A953	CESC	TCGA	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.E1597Q	TCGA-VS-A953	CESC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1111
p.E1597Q	DO219727	CESC	ICGC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation rewiring degron network	0.1111
p.E1597Q	DO219727	CESC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation rewiring degron network	0.1111
p.S2287L	DO225332	BRCA	ICGC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.1944
p.S2170F	DO218060	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation altering degron motif	0.7982
p.R2247Q	DO228483	BRCA	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.1389
p.R2247Q	DO228483	BRCA	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1944
p.R2247Q	DO229003	COCA	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.1389
p.R2247Q	DO229003	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1944
p.R2247Q	DO229005	COCA	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.1389
p.R2247Q	DO229005	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1944
p.R2247Q	DO230525	LUSC	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.1389
p.R2247Q	DO230525	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1944
p.R2247Q	DO230554	LUSC	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.1389
p.R2247Q	DO230554	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1944
p.K2262N	DO230312	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation substituting flanking lysine	0.2778
p.T209A	DO227614	COCA	ICGC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation blocking phosphorylation signal	0.6389
p.A2039V	DO222769	COCA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.2778
p.G2044S	DO234230	ESAD	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.1389
p.R1583H	DO234286	ESAD	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation altering degron motif	0.8244
p.R2520K	DO234445	ESAD	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation altering degron motif	0.6126
p.R2134H	DO233179	GACA	ICGC	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation rewiring degron network	0.25
p.G2437C	DO233259	GACA	ICGC	PETSS	DEG_SPOP_SBC_1	2431:2435	Mutation rewiring degron network	0.2778
p.R2030H	DO233270	GACA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.2778
p.D2285N	DO233272	GACA	ICGC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.25
p.R2479C	DO233916	GACA	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation altering degron motif	0.8301
p.C895F	DO228924	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.0833
p.V2258F	DO228948	LICA	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation altering degron motif	0.7068
p.R2520M	DO228952	LICA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation altering degron motif	0.7521
p.C681S	DO228862	LICA	ICGC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation altering degron motif	0.643
p.L848F	DO228974	LICA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.587
p.L848F	DO229045	LICA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.587
p.R1306G	DO229029	LICA	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.2222
p.A2263S	DO229029	LICA	ICGC	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation rewiring degron network	0.3056
p.A2263S	DO229029	LICA	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.2778
p.A2263S	DO229029	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1389
p.A2263S	DO229029	LICA	ICGC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation rewiring degron network	0.0556
p.C2531F	DO229025	LICA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.0556
p.R2245C	DO229062	LICA	ICGC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.0833
p.R2245C	DO229062	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1389
p.G189V	DO229006	LICA	ICGC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1111
p.K2166I	DO50888	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.2778
p.P2282L	DO52365	LUSC	ICGC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.7582
p.P2282L	SIDM00525	Osteosarcoma	GDSC	NGQGIYSVKP	CBL_PTK	2273:2282	Mutation altering degron motif	0.7582
p.R2265T	DO231201	LUSC	ICGC	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation altering degron motif	0.7876
p.V2047M	DO220844	MELA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.0556
p.P851S	DO220882	MELA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.3056
p.P2524L	DO222363	MELA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.25
p.KE911KK	DO222390	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation substituting flanking lysine	0.1111
p.S1289N	DO222702	MELA	ICGC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.0556
p.S906I	DO46424	OV	ICGC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation altering degron motif	0.7341
p.T2457S	DO49439	PACA	ICGC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation altering degron motif	0.6005
p.M2158I	DO219952	SARC	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.0556
p.M2158I	SIDM00310	Mesothelioma	GDSC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.0556
p.E2138K	DO219952	SARC	ICGC	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation altering degron motif	0.591
p.E2182Q	DO219952	SARC	ICGC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.0556
p.E834G	DO229221	THCA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.0556
p.R309C	DO229248	THCA	ICGC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.N839I	DO229542	UTCA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1944
p.V2529I	SIDM02039	Colorectal Carcinoma	GDSC	LEITPRRS	DEG_SCF_FBW7_1	2514:2521	Mutation rewiring degron network	0.1111
p.A2168V	SIDM01943	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation altering degron motif	0.5825
p.R2470H	SIDM01951	Colorectal Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.1111
p.V2253A	SIDM00340	Plasma Cell Myeloma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM00437	Acute Myeloid Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM00487	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM00160	Biliary Tract Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM01776	Plasma Cell Myeloma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM01446	Glioblastoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.V2253A	SIDM01587	Bladder Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation altering degron motif	0.5825
p.T1311P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.0833
p.T1311P	ACH-000914	Lymphoma	CCLE	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.0833
p.T1311P	HT	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	1299:1302	Mutation rewiring degron network	0.0833
p.K2495R	SIDM00969	Ovarian Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation substituting flanking lysine	0.1944
p.K2495R	DOV13	ovary	COSMIC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation substituting flanking lysine	0.1944
p.T2453I	SIDM00454	Rhabdomyosarcoma	GDSC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation altering degron motif	0.8189
p.T2453I	ACH-000689	Sarcoma	CCLE	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation altering degron motif	0.8189
p.T2453I	RH-18	soft tissue	COSMIC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation altering degron motif	0.8189
p.G2034R	SIDM01652	Non-Cancerous	GDSC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation altering degron motif	0.7568
p.G2034R	SIDM00187	Kidney Carcinoma	GDSC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation altering degron motif	0.7568
p.R2179T	SIDM00678	Bladder Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1389
p.R2179T	ACH-000724	Bladder Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1389
p.R2179T	HT-1376	urinary tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1389
p.Y187C	SIDM00722	Mesothelioma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.0556
p.S1594L	SIDM01199	Hepatocellular Carcinoma	GDSC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation blocking phosphorylation signal	0.6389
p.S1594L	SIDM01199	Hepatocellular Carcinoma	GDSC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation blocking phosphorylation signal	0.6389
p.S1594L	ACH-000493	Liver Cancer	CCLE	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation blocking phosphorylation signal	0.6389
p.S1594L	ACH-000493	Liver Cancer	CCLE	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation blocking phosphorylation signal	0.6389
p.S1594L	SNU-423	liver	COSMIC	VSLHKE	LIG_APCC_ABBA_1	1584:1589	Mutation blocking phosphorylation signal	0.6389
p.S1594L	SNU-423	liver	COSMIC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	1583:1589	Mutation blocking phosphorylation signal	0.6389
p.E899K	SIDM01175	Other Sarcomas	GDSC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.1944
p.E899K	ACH-002309	Sarcoma	CCLE	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.1944
p.E899K	SW684	soft tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.1944
p.S2161P	SIDM00193	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1389
p.S2161P	ACH-000991	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1389
p.S2161P	SNU-81	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	2168:2172	Mutation rewiring degron network	0.1389
p.G843V	SIDM00227	Neuroblastoma	GDSC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.3056
p.G843V	GI-ME-N	autonomic ganglia	COSMIC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.3056
p.V2469L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.0833
p.V2469L	ACH-000843	Lung Cancer	CCLE	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.0833
p.V2469L	HARA	lung	COSMIC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.0833
p.R670C	SIDM00014	Colorectal Carcinoma	GDSC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1667
p.R670C	LIM1215	large intestine	COSMIC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1667
p.G901A	SIDM00779	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.25
p.K2262R	SIDM01045	Endometrial Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation substituting flanking lysine	0.2778
p.K2262R	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation substituting flanking lysine	0.2778
p.K2262R	EN	endometrium	COSMIC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation substituting flanking lysine	0.2778
p.P2461S	SIDM00177	Melanoma	GDSC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.2222
p.P2461S	ACH-002338	Skin Cancer	CCLE	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.2222
p.P2461S	ACH-002510	Skin Cancer	CCLE	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.2222
p.S896T	SIDM00149	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.1111
p.S896T	LOXIMVI	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.1111
p.S2264F	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation altering degron motif	0.6871
p.S2264F	ACH-000873	Esophageal Cancer	CCLE	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation altering degron motif	0.6871
p.S2264F	KYSE-270	oesophagus	COSMIC	SRGGLPSLA	DEG_APCC_DBOX_1	2264:2272	Mutation altering degron motif	0.6871
p.H292R	SIDM01133	Other Solid Cancers	GDSC	PLTTS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1111
p.L2458V	SIDM00271	Gastric Carcinoma	GDSC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.3056
p.L2458V	ACH-000351	Gastric Cancer	CCLE	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.3056
p.L2458V	MKN1	stomach	COSMIC	IPTPTMT	DEG_SCF_FBW7_1	2451:2457	Mutation rewiring degron network	0.3056
p.G2244V	SIDM00124	Kidney Carcinoma	GDSC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.0556
p.G2244V	SIDM00124	Kidney Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1111
p.G2244V	ACH-000555	Kidney Cancer	CCLE	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.0556
p.G2244V	ACH-000555	Kidney Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1111
p.G2244V	A498	kidney	COSMIC	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.0556
p.G2244V	A498	kidney	COSMIC	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1111
p.A2031V	SIDM00079	Ovarian Carcinoma	GDSC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.3056
p.A2031V	ACH-000811	Ovarian Cancer	CCLE	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.3056
p.A2031V	SK-OV-3	ovary	COSMIC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation rewiring degron network	0.3056
p.R670H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1667
p.R670H	ACH-000937	Leukemia	CCLE	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1667
p.R670H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1667
p.P2035L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation altering degron motif	0.6471
p.P2035L	PF-382	haematopoietic and lymphoid tissue	COSMIC	DSGPVS	DEG_SCF_TRCP1_1	2032:2037	Mutation altering degron motif	0.6471
p.V2469E	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.0833
p.V2469E	Farage	haematopoietic and lymphoid tissue	COSMIC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation rewiring degron network	0.0833
p.S688G	SIDM01613	Colorectal Carcinoma	GDSC	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.1944
p.S191C	SIDM01611	Endometrial Carcinoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.S191C	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation rewiring degron network	0.1667
p.T202N	SIDM01611	Endometrial Carcinoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation altering degron motif	0.5944
p.T202N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGETPTLE	DEG_SCF_FBW7_2	197:204	Mutation altering degron motif	0.5944
p.S841F	SIDM01699	Chondrosarcoma	GDSC	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.25
p.S841F	ACH-000224	Non-Cancerous	CCLE	LGTPLKS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.25
p.R2486T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation altering degron motif	0.6765
p.R2486T	ACH-000777	Esophageal Cancer	CCLE	SRSKLQELR	DEG_APCC_DBOX_1	2478:2486	Mutation altering degron motif	0.6765
p.R2245H	ACH-001441	Eye Cancer	CCLE	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.0833
p.R2245H	ACH-001441	Eye Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1389
p.R2245H	ACH-001559	Lung Cancer	CCLE	TSSVVPEA	DEG_COP1_1	2254:2261	Mutation rewiring degron network	0.0833
p.R2245H	ACH-001559	Lung Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	2252:2256	Mutation rewiring degron network	0.1389
p.R2134C	ACH-001515	Cervical Cancer	CCLE	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation rewiring degron network	0.25
p.K2127R	ACH-002659	Colon/Colorectal Cancer	CCLE	AESST	DEG_SPOP_SBC_1	2137:2141	Mutation substituting flanking lysine	0.1667
p.S692F	ACH-002785	Unknown	CCLE	PSLTPCST	DEG_SCF_FBW7_1	676:683	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZD2

UniProt ID: O15018

Entrez ID: 23037

Protein name: PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZD2 in