DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_APCC_DBOX_1

Location: 2478:2486

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.991

ASA_SCORE: 101.1444

COIL: 0.4594

CONS_SCORE: 0.4849

DSS_SCORE: 0.5642

HELIX: 0.5176

FCONS_SCORE: 1.0209

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2494G	TCGA-AP-A0LM	UCEC	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	0.1111
p.D2494G	DO43306	UCEC	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	0.1111
p.S2475L	TCGA-D1-A103	UCEC	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	0.6944
p.S2475L	DO42312	UCEC	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	0.6944
p.L2493I	TCGA-DU-6392	LGG	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	0.1389
p.L2493I	DO22237	LGG	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	0.1389
p.T2472M	TCGA-EA-A3HS	CESC	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	0.6111
p.T2472M	DO6260	CESC	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	0.6111
p.E2484K	TCGA-GC-A3OO	BLCA	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	0.591
p.E2484K	DO518	BLCA	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	0.591
p.V2477M	TCGA-IG-A5S3	ESCA	TCGA	SRSKLQELR	DEG_APCC_DBOX_1	0.3056
p.R2479C	DO233916	GACA	ICGC	SRSKLQELR	DEG_APCC_DBOX_1	0.8301
p.R2470H	SIDM01951	Colorectal Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	0.1111
p.K2495R	SIDM00969	Ovarian Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	0.1944
p.K2495R	DOV13	ovary	COSMIC	SRSKLQELR	DEG_APCC_DBOX_1	0.1944
p.V2469L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	0.0833
p.V2469L	ACH-000843	Lung Cancer	CCLE	SRSKLQELR	DEG_APCC_DBOX_1	0.0833
p.V2469L	HARA	lung	COSMIC	SRSKLQELR	DEG_APCC_DBOX_1	0.0833
p.V2469E	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	0.0833
p.V2469E	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	SRSKLQELR	DEG_APCC_DBOX_1	0.0833
p.R2486T	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	SRSKLQELR	DEG_APCC_DBOX_1	0.6765
p.R2486T	ACH-000777	Esophageal Cancer	CCLE	SRSKLQELR	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_APCC_DBOX_1	2478:2486	SRSKLQELR	APC,CDC20,FZR1	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons