DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SCF_FBW7_1

Location: 844:850

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 82.3571

COIL: 0.9211

CONS_SCORE: 0.4193

DSS_SCORE: 0.5885

HELIX: 0.0239

FCONS_SCORE: 1.0136

RIG_SCORE: 0.6284

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L848F	DO228974	LICA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	0.587
p.L848F	DO229045	LICA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	0.587
p.P851S	DO220882	MELA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	0.3056
p.G843V	SIDM00227	Neuroblastoma	GDSC	LGTPLKS	DEG_SCF_FBW7_1	0.3056
p.G843V	GI-ME-N	autonomic_ganglia	COSMIC	LGTPLKS	DEG_SCF_FBW7_1	0.3056
p.S841F	SIDM01699	Chondrosarcoma	GDSC	LGTPLKS	DEG_SCF_FBW7_1	0.25
p.S841F	ACH-000224	Non-Cancerous	CCLE	LGTPLKS	DEG_SCF_FBW7_1	0.25
p.A854E	TCGA-VR-A8EQ	ESCA	TCGA	LGTPLKS	DEG_SCF_FBW7_1	0.2222
p.N839I	DO229542	UTCA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	0.1944
p.E834G	DO229221	THCA	ICGC	LGTPLKS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SCF_FBW7_1	844:850	LGTPLKS	FBXW7	0.9946	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons