DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SPOP_SBC_1

Location: 300:304

E3 ligase: SPOP

DEGRON score: 0.9856

ASA_SCORE: 81.76

COIL: 0.849

CONS_SCORE: 0.2726

DSS_SCORE: 0.6144

HELIX: 0.058

FCONS_SCORE: 0.872

RIG_SCORE: 0.687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P295S	TCGA-56-7222	LUSC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1944
p.P295S	DO26842	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.T297A	TCGA-AA-A00N	COAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.25
p.T297A	DO9876	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.25
p.R308C	TCGA-CG-4442	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2222
p.R308C	TCGA-P3-A6SW	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2222
p.R308C	DO227668	COCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.R308C	DO49062	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.R308C	DO38380	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.D298N	TCGA-CN-4739	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2778
p.D298N	DO14478	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2778
p.D298A	TCGA-CN-4739	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2778
p.D298A	DO14478	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2778
p.T302N	TCGA-D7-6526	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7055
p.T302N	DO38803	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7055
p.S311L	TCGA-EE-A2MM	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1389
p.S311L	DO222678	MELA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.S311L	DO37770	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.G313C	TCGA-FY-A40L	THCA	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0833
p.G313C	DO39028	THCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.P295L	TCGA-GN-A269	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1944
p.P295L	DO37483	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.R309C	DO229248	THCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.H292R	SIDM01133	Other Solid Cancers	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons