DegronMD

Uniprot ID: A7MD48

Source protein: Serine/arginine repetitive matrix protein 4

Source gene: SRRM4

Class: DEG_SPOP_SBC_1

Location: 274:278

E3 ligase: SPOP

DEGRON score: 0.9836

ASA_SCORE: 93.16

COIL: 0.9176

CONS_SCORE: 0.4229

DSS_SCORE: 0.574

HELIX: 0.0526

FCONS_SCORE: 0.6411

RIG_SCORE: 0.6816

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S282F	TCGA-06-5416	GBM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2222
p.S282F	DO10880	GBM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.R279P	TCGA-55-8302	LUAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.3056
p.R279P	DO45312	LUAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.3056
p.S278L	TCGA-A5-A0G2	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7667
p.S278L	TCGA-D3-A2JF	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7667
p.S278L	DO229470	SKCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7667
p.S278L	DO38153	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7667
p.S278L	DO41235	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7667
p.Q283H	TCGA-AP-A1DK	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1944
p.Q283H	DO42033	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.A265V	TCGA-D1-A16F	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0833
p.A265V	DO42408	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.A265V	SIDM00151	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.A265V	IGROV-1	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.P274S	TCGA-GN-A266	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.6752
p.P274S	DO37432	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.6752
p.P274L	TCGA-HT-7616	LGG	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P274L	DO22422	LGG	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P274L	SIDM00537	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P274L	ACH-000982	Colon/Colorectal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P274L	ACH-001345	Colon/Colorectal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P274L	GP5d	large_intestine	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.7582
p.A272D	TCGA-P4-A5E7	KIRP	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2778
p.A272D	DO48479	KIRP	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2778
p.S273N	DO234350	ESAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.3056
p.T269S	DO229493	LAML	ICGC	PLTTS	DEG_SPOP_SBC_1	0.6389
p.R281L	DO229029	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.25
p.L267V	SIDM00255	Neuroblastoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.L267V	ACH-002282	Neuroblastoma	CCLE	PLTTS	DEG_SPOP_SBC_1	0.1389
p.L267V	NB17	autonomic_ganglia	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.L267I	ACH-000788	Skin Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTTS

Degron related mutations and impact score

Drug responses associated with SRRM4 mutations

All proteins holding degron of PLTTS