DegronMD

Uniprot ID: Q9P107

Source protein: GEM-interacting protein

Source gene: GMIP

Class: DEG_SPOP_SBC_1

Location: 779:783

E3 ligase: SPOP

DEGRON score: 0.6642

ASA_SCORE: 90.8

COIL: 0.925

CONS_SCORE: 0.2831

DSS_SCORE: 0.9391

HELIX: 0.0298

FCONS_SCORE: 1.0004

RIG_SCORE: 0.4726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P777T	TCGA-F7-A624	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2778
p.P789L	TCGA-FI-A2D0	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1667
p.D792N	TCGA-PK-A5HB	ACC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0833
p.T793R	DO222878	BTCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.H785R	DO44440	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2778
p.Q790H	DO228916	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.P772S	DO228947	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.P772S	DO230522	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.P772S	DO231102	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.T787N	DO228976	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.S769F	DO47569	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.Q770R	DO47833	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.S774I	SIDM00135	Breast Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S774I	SIDM01123	Prostate Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S774I	SIDM00841	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S774I	SIDM00534	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S774I	SIDM01566	Hodgkin's Lymphoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.P770H	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.P770H	ACH-000378	Lung Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.0833
p.P779L	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P779L	ACH-000066	Lung Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons