DegronMD

Uniprot ID: Q9NQU5

Source protein: Serine/threonine-protein kinase PAK 6

Source gene: PAK6

Class: DEG_SPOP_SBC_1

Location: 320:324

E3 ligase: SPOP

DEGRON score: 0.9576

ASA_SCORE: 91.08

COIL: 0.9296

CONS_SCORE: 0.2516

DSS_SCORE: 0.7266

HELIX: 0.0326

FCONS_SCORE: 0.9719

RIG_SCORE: 0.632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R334H	TCGA-AA-A01P	COAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	TCGA-IB-7651	PAAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	DO8642	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	DO46657	PAAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	SIDM01040	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	ACH-000574	Ovarian Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	ACH-001737	Leukemia	CCLE	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334H	FU-OV-1	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.L333P	TCGA-AP-A1DK	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0833
p.L333P	DO42033	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.S324L	TCGA-BR-8680	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7667
p.S324L	DO47769	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7667
p.P329L	TCGA-CJ-4636	KIRC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1944
p.P329L	DO19298	KIRC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.L333F	TCGA-DU-6407	LGG	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0833
p.L333F	DO22295	LGG	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.P320S	TCGA-FW-A3R5	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.6752
p.P320S	DO37406	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.6752
p.P314L	DO222671	ESCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1667
p.R334C	SIDM00014	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334C	SIDM00383	Gastric Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0556
p.R334C	SIDM01111	Ewing's Sarcoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons