DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PLTTS
Uniprot ID:
Q96RV3
Source protein:
Pecanex-like protein 1
Source gene:
PCNX1
Class:
DEG_SPOP_SBC_1
Location:
715:719
E3 ligase:
SPOP
DEGRON score:
0.9997
ASA_SCORE:
70.96
COIL:
0.9232
CONS_SCORE:
0.3835
DSS_SCORE:
0.4894
HELIX:
0.0334
FCONS_SCORE:
0.9963
RIG_SCORE:
0.7156
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PCNX1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A7MD48
Serine/arginine repetitive matrix protein 4
DEG_SPOP_SBC_1
274:278
PLTTS
SPOP
0.9836
More...
O15018
PDZ domain-containing protein 2
DEG_SPOP_SBC_1
300:304
PLTTS
SPOP
0.9856
More...
P29074
Tyrosine-protein phosphatase non-receptor type 4
DEG_SPOP_SBC_1
919:923
PLTTS
SPOP
0.847
More...
Q14246
Adhesion G protein-coupled receptor E1
DEG_SPOP_SBC_1
501:505
PLTTS
SPOP
0.7492
More...
Q5SW79
Centrosomal protein of 170 kDa
DEG_SPOP_SBC_1
562:566
PLTTS
SPOP
0.994
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
187:191
PLTTS
SPOP
0.968
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
9734:9738
PLTTS
SPOP
0.8464
More...
Q9NQU5
Serine/threonine-protein kinase PAK 6
DEG_SPOP_SBC_1
320:324
PLTTS
SPOP
0.9576
More...
Q9P107
GEM-interacting protein
DEG_SPOP_SBC_1
779:783
PLTTS
SPOP
0.6642
More...
Q96RV3
Pecanex-like protein 1
DEG_SPOP_SBC_1
715:719
PLTTS
SPOP
0.9997
More...
Q96RV3
Pecanex-like protein 1
DEG_SPOP_SBC_1
1997:2001
PLTTS
SPOP
0.9692
More...
Q9Y2D9
Zinc finger protein 652
DEG_SPOP_SBC_1
507:511
PLTTS
SPOP
0.9882
More...
Q9P2C4
Transmembrane protein 181
DEG_SPOP_SBC_1
47:51
PLTTS
SPOP
0.6212
More...
Q0P670
Uncharacterized protein SPEM2
DEG_SPOP_SBC_1
397:401
PLTTS
SPOP
0.9988
More...