DegronMD

Uniprot ID: Q14246

Source protein: Adhesion G protein-coupled receptor E1

Source gene: ADGRE1

Class: DEG_SPOP_SBC_1

Location: 501:505

E3 ligase: SPOP

DEGRON score: 0.7492

ASA_SCORE: 78.94

COIL: 0.836

CONS_SCORE: 0.3536

DSS_SCORE: 0.295

HELIX: 0.1014

FCONS_SCORE: 0.5937

RIG_SCORE: 0.8023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M511I	SIDM00140	Melanoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.1667
p.M511I	COLO-792	skin	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.1667
p.H498N	SIDM00220	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.25
p.H498N	OC-314	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.25
p.T511I	SBC-3	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.1667
p.F494L	SHP-77	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.L515F	HCC1569	breast	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons