DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9734:9738

E3 ligase: SPOP

DEGRON score: 0.8464

ASA_SCORE: 89.74

COIL: 0.8734

CONS_SCORE: 0

DSS_SCORE: 0.3671

HELIX: 0.0156

FCONS_SCORE: 0

RIG_SCORE: 0.7091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9727P	TCGA-02-2466	GBM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1389
p.S9727P	DO13480	GBM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1389
p.T9737I	TCGA-A6-2686	COAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7078
p.T9737I	DO7828	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7078
p.S9729Y	TCGA-D1-A17Q	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S9729Y	DO41903	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S9729F	TCGA-EB-A41B	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1944
p.S9729F	DO37611	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.P9734L	TCGA-EE-A29E	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7582
p.P9734L	DO37831	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7582
p.L9735I	TCGA-EO-A22R	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.6063
p.L9735I	DO42713	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.6063
p.P9734H	TCGA-EO-A22R	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.7694
p.P9734H	DO42713	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7694
p.S9738P	DO233804	GACA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7863
p.S9729C	DO50814	LIRI	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.R9725K	DO220903	MELA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.L9735V	SIDM00989	Bladder Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.5654
p.L9735V	ACH-000802	Bladder Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.5654
p.L9735V	BFTC-905	urinary_tract	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.5654
p.L9739I	SIDM01335	Kidney Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.3056
p.L9747I	SIDM01511	Gastric Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.L9747I	ACH-000746	Gastric Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.0833
p.S9740Y	ACH-001388	Breast Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.7222
p.S9727F	ACH-001982	Metastasis	CCLE	PLTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons