DegronMD - A7MD48(SRRM4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S282F	TCGA-06-5416	GBM	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.2222
p.S282F	TCGA-06-5416	GBM	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.S282F	DO10880	GBM	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.2222
p.S282F	DO10880	GBM	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2222
p.A22V	TCGA-2W-A8YY	CESC	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.3056
p.A22V	TCGA-DF-A2KU	UCEC	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.3056
p.A22V	DO223732	CESC	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.3056
p.A22V	DO223286	UCEC	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.3056
p.R279P	TCGA-55-8302	LUAD	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.1389
p.R279P	TCGA-55-8302	LUAD	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.3056
p.R279P	DO45312	LUAD	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.1389
p.R279P	DO45312	LUAD	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.3056
p.G288E	TCGA-55-A494	LUAD	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.7199
p.G288E	DO23794	LUAD	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.7199
p.G288E	DO222837	MELA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.7199
p.S292A	TCGA-60-2708	LUSC	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.6477
p.S292A	DO26431	LUSC	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.6477
p.P339T	TCGA-60-2726	LUSC	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.2222
p.P339T	DO27484	LUSC	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.2222
p.P26T	TCGA-66-2794	LUSC	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation altering degron motif	0.7031
p.P26T	DO26683	LUSC	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation altering degron motif	0.7031
p.S278L	TCGA-A5-A0G2	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S278L	TCGA-D3-A2JF	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S278L	DO229470	SKCA	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S278L	DO38153	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.S278L	DO41235	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7667
p.A344V	TCGA-AA-3947	COAD	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0833
p.A344V	DO8192	COAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0833
p.Q283H	TCGA-AP-A1DK	UCEC	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.25
p.Q283H	TCGA-AP-A1DK	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1944
p.Q283H	DO42033	UCEC	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.25
p.Q283H	DO42033	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1944
p.T37M	TCGA-B5-A0K9	UCEC	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1111
p.T37M	TCGA-DY-A1H8	READ	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1111
p.T37M	DO37181	READ	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1111
p.T37M	DO42097	UCEC	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1111
p.S300N	TCGA-B5-A1MX	UCEC	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.1111
p.S300N	DO41999	UCEC	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.1111
p.I32N	TCGA-BR-6452	STAD	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.25
p.I32N	DO38404	STAD	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.25
p.R320Q	TCGA-CM-6169	COAD	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0833
p.R320Q	DO8344	COAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0833
p.R320Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0833
p.R320Q	SIDM01580	Melanoma	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0833
p.A265V	TCGA-D1-A16F	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.0833
p.A265V	DO42408	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.0833
p.A265V	SIDM00151	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.0833
p.A265V	IGROV-1	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.0833
p.H92R	TCGA-DI-A1BU	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.1111
p.H92R	DO42023	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.1111
p.A302S	TCGA-DK-A2I1	BLCA	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.0556
p.A302S	DO444	BLCA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.0556
p.E13Q	TCGA-DK-AA76	BLCA	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.0556
p.E13Q	DO219013	BLCA	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.0556
p.G18E	TCGA-EO-A22U	UCEC	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1944
p.G18E	DO43755	UCEC	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1944
p.P104L	TCGA-ER-A193	SKCM	TCGA	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6471
p.P104L	DO47368	SKCM	ICGC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6471
p.T25N	TCGA-EW-A1OY	BRCA	TCGA	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation altering degron motif	0.8166
p.T25N	DO2743	BRCA	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation altering degron motif	0.8166
p.P274S	TCGA-GN-A266	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.6752
p.P274S	DO37432	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.6752
p.P274L	TCGA-HT-7616	LGG	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7582
p.P274L	DO22422	LGG	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7582
p.P274L	SIDM00537	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7582
p.P274L	ACH-000982	Colon/Colorectal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7582
p.P274L	ACH-001345	Colon/Colorectal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7582
p.P274L	GP5d	large intestine	COSMIC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation altering degron motif	0.7582
p.A272D	TCGA-P4-A5E7	KIRP	TCGA	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2778
p.A272D	DO48479	KIRP	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.2778
p.N326S	TCGA-QK-A8Z7	HNSC	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.25
p.N326S	DO52096	HNSC	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.25
p.A24T	DO222501	COCA	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation altering degron motif	0.6028
p.N332T	DO50342	ESAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation altering degron motif	0.5944
p.A34V	DO10839	ESAD	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.1944
p.T336A	DO234321	ESAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.3056
p.S273N	DO234350	ESAD	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.3056
p.Q340L	DO233129	GACA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.1944
p.D286N	DO233935	GACA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.6932
p.S328F	DO233941	GACA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.3056
p.T269S	DO229493	LAML	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation blocking phosphorylation signal	0.6389
p.R281L	DO229029	LICA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation rewiring degron network	0.1944
p.R281L	DO229029	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.25
p.Q340H	DO229032	LICA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.1944
p.E321Q	DO23250	LINC	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.1111
p.P102L	DO50814	LIRI	ICGC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7582
p.K112N	DO230946	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation substituting flanking lysine	0.25
p.K112N	DO224605	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation substituting flanking lysine	0.25
p.R90I	DO231186	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.R90I	SIDM01107	Melanoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.R90I	ACH-000465	Skin Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.R90I	SK-MEL-1	skin	COSMIC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.T25P	DO231102	LUSC	ICGC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation altering degron motif	0.8142
p.N326Y	DO220893	MELA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.25
p.G343E	DO229453	SKCA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.1111
p.A38V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.0833
p.A38V	ACH-000914	Lymphoma	CCLE	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.0833
p.A38V	HT	haematopoietic and lymphoid tissue	COSMIC	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.0833
p.S319I	SIDM00570	Gastric Carcinoma	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0556
p.S319I	ACH-000674	Gastric Cancer	CCLE	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.0556
p.S324C	SIDM00845	Burkitt's Lymphoma	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	329:335	Mutation rewiring degron network	0.1944
p.P102S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6752
p.P102S	ACH-000860	Lung Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6752
p.P102S	NCI-H358	lung	COSMIC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6752
p.G91E	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0833
p.G91E	ACH-000757	Lung Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0833
p.G91E	A427	lung	COSMIC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0833
p.L267V	SIDM00255	Neuroblastoma	GDSC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.L267V	ACH-002282	Neuroblastoma	CCLE	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.L267V	NB17	autonomic ganglia	COSMIC	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.K111T	SIDM00534	Colorectal Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation substituting flanking lysine	0.2778
p.K111T	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation substituting flanking lysine	0.2778
p.K111T	HT-115	large intestine	COSMIC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation substituting flanking lysine	0.2778
p.S287L	SIDM01782	Oral Cavity Carcinoma	GDSC	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.7667
p.S287L	ACH-000723	Head and Neck Cancer	CCLE	DSGNDTS	DEG_SCF_TRCP1_1	286:292	Mutation altering degron motif	0.7667
p.L267I	ACH-000788	Skin Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	274:278	Mutation rewiring degron network	0.1389
p.R39L	ACH-000872	Lung Cancer	CCLE	VATPRPE	DEG_SCF_FBW7_2	23:29	Mutation rewiring degron network	0.0556
p.S105F	ACH-002396	Bone Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7982
p.S105F	Sarc9371	bone	COSMIC	LTPPPS	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRRM4

UniProt ID: A7MD48

Entrez ID: 84530

Protein name: Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SRRM4 in