DegronMD

Uniprot ID: A7MD48

Source protein: Serine/arginine repetitive matrix protein 4

Source gene: SRRM4

Class: DEG_SCF_FBW7_2

Location: 23:29

E3 ligase: FBXW7

DEGRON score: 0.6786

ASA_SCORE: 80.6286

COIL: 0.739

CONS_SCORE: 0.9676

DSS_SCORE: 0.3062

HELIX: 0.0474

FCONS_SCORE: 1.0091

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A22V	TCGA-2W-A8YY	CESC	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.3056
p.A22V	TCGA-DF-A2KU	UCEC	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.3056
p.A22V	DO223732	CESC	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.3056
p.A22V	DO223286	UCEC	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.3056
p.P26T	TCGA-66-2794	LUSC	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.7031
p.P26T	DO26683	LUSC	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.7031
p.T37M	TCGA-B5-A0K9	UCEC	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.1111
p.T37M	TCGA-DY-A1H8	READ	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.1111
p.T37M	DO37181	READ	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.1111
p.T37M	DO42097	UCEC	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.1111
p.I32N	TCGA-BR-6452	STAD	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.25
p.I32N	DO38404	STAD	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.25
p.E13Q	TCGA-DK-AA76	BLCA	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.0556
p.E13Q	DO219013	BLCA	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.0556
p.G18E	TCGA-EO-A22U	UCEC	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.1944
p.G18E	DO43755	UCEC	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.1944
p.T25N	TCGA-EW-A1OY	BRCA	TCGA	VATPRPE	DEG_SCF_FBW7_2	0.8166
p.T25N	DO2743	BRCA	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.8166
p.A24T	DO222501	COCA	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.6028
p.A34V	DO10839	ESAD	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.1944
p.T25P	DO231102	LUSC	ICGC	VATPRPE	DEG_SCF_FBW7_2	0.8142
p.A38V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VATPRPE	DEG_SCF_FBW7_2	0.0833
p.A38V	ACH-000914	Lymphoma	CCLE	VATPRPE	DEG_SCF_FBW7_2	0.0833
p.A38V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VATPRPE	DEG_SCF_FBW7_2	0.0833
p.R39L	ACH-000872	Lung Cancer	CCLE	VATPRPE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_FBW7_2	23:29	VATPRPE	FBXW7	0.6786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons