DegronMD

Uniprot ID: A7MD48

Source protein: Serine/arginine repetitive matrix protein 4

Source gene: SRRM4

Class: DEG_SCF_FBW7_1

Location: 100:105

E3 ligase: FBXW7

DEGRON score: 0.8885

ASA_SCORE: 92.4833

COIL: 0.9717

CONS_SCORE: 0.6323

DSS_SCORE: 0.8494

HELIX: 0.0143

FCONS_SCORE: 0.8928

RIG_SCORE: 0.5531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H92R	TCGA-DI-A1BU	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.1111
p.H92R	DO42023	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1111
p.P104L	TCGA-ER-A193	SKCM	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.6471
p.P104L	DO47368	SKCM	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6471
p.P102L	DO50814	LIRI	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7582
p.K112N	DO230946	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.25
p.K112N	DO224605	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.25
p.R90I	DO231186	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.R90I	SIDM01107	Melanoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.R90I	ACH-000465	Skin Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.R90I	SK-MEL-1	skin	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.P102S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.6752
p.P102S	ACH-000860	Lung Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.6752
p.P102S	NCI-H358	lung	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.6752
p.G91E	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.0833
p.G91E	ACH-000757	Lung Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.0833
p.G91E	A427	lung	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.0833
p.K111T	SIDM00534	Colorectal Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.K111T	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.K111T	HT-115	large_intestine	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.S105F	ACH-002396	Bone Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.7982
p.S105F	Sarc9371	bone	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_FBW7_1	100:105	LTPPPS	FBXW7	0.8885	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SCF_FBW7_1	425:430	LTPPPS	FBXW7	0.999	More...
Q13887	Krueppel-like factor 5	DEG_SCF_FBW7_1	322:327	LTPPPS	FBXW7	0.9988	More...
Q8TB72	Pumilio homolog 2	DEG_SCF_FBW7_1	635:640	LTPPPS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons