DegronMD - Q13887(KLF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S334Y	TCGA-AX-A2HD	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.1389
p.S334Y	TCGA-AX-A2HD	UCEC	TCGA	PPSY	ITCH	325:328	Mutation rewiring degron network	0.1667
p.S334Y	DO42608	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.1389
p.S334Y	DO42608	UCEC	ICGC	PPSY	ITCH	325:328	Mutation rewiring degron network	0.1667
p.P312S	TCGA-IB-7651	PAAD	TCGA	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.0556
p.P312S	DO46657	PAAD	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.0556
p.D327G	DO51931	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.7198
p.D327G	DO51931	BLCA	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7198
p.D327G	DO47851	STAD	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.7198
p.D327G	DO47851	STAD	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7198
p.D327N	DO51903	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.6932
p.D327N	DO51903	BLCA	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6932
p.D327N	DO219010	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.6932
p.D327N	DO219010	BLCA	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6932
p.D327N	DO45491	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.6932
p.D327N	DO45491	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6932
p.F323L	DO51886	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.6981
p.D327Y	DO219066	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.7325
p.D327Y	DO219066	BLCA	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7325
p.D320Y	DO563	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.2778
p.D320Y	DO563	BLCA	ICGC	PPSY	ITCH	325:328	Mutation rewiring degron network	0.1944
p.E328K	DO737	BLCA	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328K	DO219732	CESC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328K	DO51640	CESC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328K	DO51627	CESC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328K	DO51599	CESC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328K	DO44299	CESC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328K	DO25985	LUAD	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7022
p.E328G	DO51640	CESC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7199
p.P312R	DO222849	COCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.0556
p.W316C	DO228313	LICA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.1667
p.W316C	DO228313	LICA	ICGC	PPSY	ITCH	325:328	Mutation rewiring degron network	0.0833
p.S326L	DO231518	LINC	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.7667
p.S326L	DO231518	LINC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7667
p.S326L	DO51303	SKCM	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation altering degron motif	0.7667
p.S326L	DO51303	SKCM	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.7667
p.M318R	DO23124	LINC	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.2222
p.M318R	DO23124	LINC	ICGC	PPSY	ITCH	325:328	Mutation rewiring degron network	0.1389
p.E328Q	DO25957	LUAD	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.E328Q	DO26520	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.E328Q	DO26452	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.E328Q	DO26707	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.E328Q	DO45453	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.E328Q	DO219121	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.E328Q	DO219183	LUSC	ICGC	PPSY	ITCH	325:328	Mutation altering degron motif	0.6744
p.T331I	DO232761	PBCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.2222
p.T331I	DO232761	PBCA	ICGC	PPSY	ITCH	325:328	Mutation rewiring degron network	0.25
p.E317D	ACH-000975	Lung Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.1944
p.E317D	ACH-000975	Lung Cancer	CCLE	PPSY	ITCH	325:328	Mutation rewiring degron network	0.1111
p.L319P	ACH-002023	Colon/Colorectal Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	322:327	Mutation rewiring degron network	0.25
p.L319P	ACH-002023	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	325:328	Mutation rewiring degron network	0.1667

Kaplan plot for KLF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF5

UniProt ID: Q13887

Entrez ID: 688

Protein name: Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF5 in