DegronMD

Uniprot ID: Q13887

Source protein: Krueppel-like factor 5

Source gene: KLF5

Class: DEG_SCF_FBW7_1

Location: 322:327

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 68.2667

COIL: 0.9323

CONS_SCORE: 0.5981

DSS_SCORE: 0.5495

HELIX: 0.0448

FCONS_SCORE: 1.2615

RIG_SCORE: 0.6512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S334Y	TCGA-AX-A2HD	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.1389
p.S334Y	DO42608	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1389
p.P312S	TCGA-IB-7651	PAAD	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.P312S	DO46657	PAAD	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.D327G	DO51931	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7198
p.D327G	DO47851	STAD	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7198
p.D327N	DO51903	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6932
p.D327N	DO219010	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6932
p.D327N	DO45491	LUSC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6932
p.F323L	DO51886	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6981
p.D327Y	DO219066	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7325
p.D320Y	DO563	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.P312R	DO222849	COCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.W316C	DO228313	LICA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1667
p.S326L	DO231518	LINC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7667
p.S326L	DO51303	SKCM	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7667
p.M318R	DO23124	LINC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.2222
p.T331I	DO232761	PBCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.2222
p.E317D	ACH-000975	Lung Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.1944
p.L319P	ACH-002023	Colon/Colorectal Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_FBW7_1	100:105	LTPPPS	FBXW7	0.8885	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SCF_FBW7_1	425:430	LTPPPS	FBXW7	0.999	More...
Q13887	Krueppel-like factor 5	DEG_SCF_FBW7_1	322:327	LTPPPS	FBXW7	0.9988	More...
Q8TB72	Pumilio homolog 2	DEG_SCF_FBW7_1	635:640	LTPPPS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons