DegronMD

Uniprot ID: P36956

Source protein: Sterol regulatory element-binding protein 1

Source gene: SREBF1

Class: DEG_SCF_FBW7_1

Location: 425:430

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 82.4833

COIL: 0.963

CONS_SCORE: 0.4553

DSS_SCORE: 0.732

HELIX: 0.0192

FCONS_SCORE: 1.4067

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L417M	TCGA-D3-A3C8	SKCM	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.1111
p.R418C	TCGA-D5-6928	COAD	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.25
p.S416T	TCGA-D8-A1JD	BRCA	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.0833
p.T419I	TCGA-DU-5852	LGG	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.1667
p.K423R	TCGA-DW-7839	KIRP	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.S426F	TCGA-E5-A4U1	BLCA	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.7982
p.V421A	TCGA-FI-A2D5	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.2222
p.L417V	TCGA-KP-A3W1	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.1111
p.H420Q	DO224965	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1944
p.H420Q	DO227820	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1944
p.M428V	DO219629	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7208
p.G434R	DO234183	ESAD	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6667
p.G434R	DO52409	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6667
p.A415T	DO52268	LIHC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.0556
p.C434R	SIDM01090	Colorectal Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.6667
p.C434R	RKO	large_intestine	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.6667
p.S432L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.S432L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.2778
p.E422D	ACH-000984	Endometrial/Uterine Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_FBW7_1	100:105	LTPPPS	FBXW7	0.8885	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SCF_FBW7_1	425:430	LTPPPS	FBXW7	0.999	More...
Q13887	Krueppel-like factor 5	DEG_SCF_FBW7_1	322:327	LTPPPS	FBXW7	0.9988	More...
Q8TB72	Pumilio homolog 2	DEG_SCF_FBW7_1	635:640	LTPPPS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons