DegronMD

Uniprot ID: Q8TB72

Source protein: Pumilio homolog 2

Source gene: PUM2

Class: DEG_SCF_FBW7_1

Location: 635:640

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 60.5167

COIL: 0.9373

CONS_SCORE: 0.4245

DSS_SCORE: 0.7355

HELIX: 0.0323

FCONS_SCORE: 1.5994

RIG_SCORE: 0.5506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T636K	TCGA-14-1396	GBM	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.7306
p.T636K	DO11429	GBM	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7306
p.P638L	TCGA-A5-A0G2	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.6471
p.P638L	DO41235	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6471
p.S647L	TCGA-C5-A1BI	CESC	TCGA	LTPPPS	DEG_SCF_FBW7_1	0.1389
p.S647L	DO48372	BLCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1389
p.S647L	DO44305	CESC	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1389
p.F635L	DO1132	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.6981
p.N637S	DO3686	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7069
p.T636M	DO48296	ESCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7423
p.T636M	SIDM00999	Bladder Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	0.7423
p.T636M	ACH-000973	Bladder Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	0.7423
p.T636M	639-V	urinary_tract	COSMIC	LTPPPS	DEG_SCF_FBW7_1	0.7423
p.P637T	DO228948	LICA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7031
p.P637Q	DO229038	LICA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7035
p.P636L	DO222423	MELA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7582
p.P636L	DO37425	SKCM	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.7582
p.S648F	DO229240	THCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_FBW7_1	100:105	LTPPPS	FBXW7	0.8885	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SCF_FBW7_1	425:430	LTPPPS	FBXW7	0.999	More...
Q13887	Krueppel-like factor 5	DEG_SCF_FBW7_1	322:327	LTPPPS	FBXW7	0.9988	More...
Q8TB72	Pumilio homolog 2	DEG_SCF_FBW7_1	635:640	LTPPPS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons