DegronMD - P36956(SREBF1)

FUNCTION: [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:8402897, PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:8402897, PubMed:12177166). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:8402897, PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F59Y	TCGA-55-8511	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation blocking phosphorylation signal	0.6389
p.F59Y	DO24940	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation blocking phosphorylation signal	0.6389
p.N68D	TCGA-A5-A0G1	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.6932
p.P224S	TCGA-CK-4951	COAD	TCGA	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.6752
p.P223L	TCGA-CK-6747	COAD	TCGA	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.3056
p.L417M	TCGA-D3-A3C8	SKCM	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1111
p.R418C	TCGA-D5-6928	COAD	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation substituting flanking lysine	0.25
p.S416T	TCGA-D8-A1JD	BRCA	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.0833
p.T419I	TCGA-DU-5852	LGG	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.K423R	TCGA-DW-7839	KIRP	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.2778
p.S426F	TCGA-E5-A4U1	BLCA	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.7982
p.V421A	TCGA-FI-A2D5	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.2222
p.S230Y	TCGA-IQ-A61I	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2778
p.L417V	TCGA-KP-A3W1	UCEC	TCGA	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1111
p.A54S	TCGA-ZB-A966	THYM	TCGA	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0556
p.H420Q	DO224965	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1944
p.H420Q	DO227820	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1944
p.M428V	DO219629	BRCA	ICGC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.7208
p.T238M	DO219731	CESC	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0556
p.T238M	DO230343	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0556
p.T238M	DO229259	THCA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.0556
p.S63F	DO51632	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation blocking phosphorylation signal	0.75
p.P76A	DO6254	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1111
p.A76T	DO8400	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1111
p.G434R	DO234183	ESAD	ICGC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation blocking phosphorylation signal	0.6667
p.G434R	DO52409	UCEC	ICGC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation blocking phosphorylation signal	0.6667
p.R233C	DO233903	GACA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.1944
p.G58D	DO17801	KIRC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.S58G	DO20942	KIRP	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.G57R	DO44584	LGG	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1389
p.P220T	DO229029	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2222
p.Q232K	DO229036	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2222
p.A62D	DO229041	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.T226K	DO229009	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7306
p.S68P	DO22959	LIHC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.6752
p.A415T	DO52268	LIHC	ICGC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.0556
p.T221M	DO23468	LINC	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.25
p.R71L	DO26695	LUSC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.25
p.S225I	DO228138	PBCA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7341
p.Q232H	DO232224	PBCA	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2222
p.I77T	DO219875	SKCA	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.R67H	DO38214	STAD	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.8244
p.S231L	DO38195	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.25
p.T72I	DO229221	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2222
p.T226M	DO40889	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7423
p.T226M	647-V	urinary tract	COSMIC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation altering degron motif	0.7423
p.R71H	DO43306	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.25
p.T221A	DO41871	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.25
p.A55T	DO41871	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.N75S	DO41235	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1389
p.R220W	DO43891	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2222
p.P76H	DO41103	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1111
p.V229I	SIDM01951	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.3056
p.V229I	SIDM00680	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.3056
p.V229I	LS-180	large intestine	COSMIC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.3056
p.C434R	SIDM01090	Colorectal Carcinoma	GDSC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation blocking phosphorylation signal	0.6667
p.C434R	RKO	large intestine	COSMIC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation blocking phosphorylation signal	0.6667
p.P74S	SIDM00190	Melanoma	GDSC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.P74S	CP66-MEL	skin	COSMIC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.P216H	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.1111
p.S432L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.2778
p.S432L	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.2778
p.S230A	SIDM00150	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2778
p.S230A	KM12	large intestine	COSMIC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.2778
p.L231V	SIDM01617	Endometrial Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.25
p.P69T	ACH-000977	lymph node	CCLE	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.3056
p.P69T	LNCaP-Clone-FGC	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.3056
p.A62V	ACH-000977	lymph node	CCLE	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.A62V	LNCaP-Clone-FGC	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.E422D	ACH-000984	Endometrial/Uterine Cancer	CCLE	LTPPPS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.25
p.A219V	ACH-001416	Bladder Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	224:228	Mutation rewiring degron network	0.1944

Kaplan plot for SREBF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SREBF1

UniProt ID: P36956

Entrez ID: 6720

Protein name: Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SREBF1 in