DegronMD

Uniprot ID: P36956

Source protein: Sterol regulatory element-binding protein 1

Source gene: SREBF1

Class: DEG_SPOP_SBC_1

Location: 224:228

E3 ligase: SPOP

DEGRON score: 0.9066

ASA_SCORE: 83.52

COIL: 0.7968

CONS_SCORE: 0.279

DSS_SCORE: 0.2693

HELIX: 0.0182

FCONS_SCORE: 0.8572

RIG_SCORE: 0.8013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P224S	TCGA-CK-4951	COAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.6752
p.P223L	TCGA-CK-6747	COAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.3056
p.S230Y	TCGA-IQ-A61I	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.2778
p.T238M	DO219731	CESC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.T238M	DO230343	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.T238M	DO229259	THCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.R233C	DO233903	GACA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1944
p.P220T	DO229029	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.Q232K	DO229036	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.T226K	DO229009	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7306
p.T221M	DO23468	LINC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.25
p.S225I	DO228138	PBCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7341
p.Q232H	DO232224	PBCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.S231L	DO38195	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.25
p.T226M	DO40889	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7423
p.T226M	647-V	urinary_tract	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.7423
p.T221A	DO41871	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.25
p.R220W	DO43891	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.V229I	SIDM01951	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.3056
p.V229I	SIDM00680	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.3056
p.V229I	LS-180	large_intestine	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.3056
p.P216H	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.S230A	SIDM00150	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.S230A	KM12	large_intestine	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L231V	SIDM01617	Endometrial Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.25
p.A219V	ACH-001416	Bladder Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons