DegronMD - A6NKB5(PCNX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S200F	SIDM00516	Melanoma	GDSC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation rewiring degron network	0.1667
p.S200F	MZ7-mel	skin	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation rewiring degron network	0.1667
p.A199V	SIDM00365	Small Cell Lung Carcinoma	GDSC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation rewiring degron network	0.1944
p.A199V	SBC-1	lung	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation rewiring degron network	0.1944
p.S186A	SIDM00217	Colorectal Carcinoma	GDSC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation altering degron motif	0.6477
p.S186A	SIDM00217	Colorectal Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7588
p.S186A	SNU-1040	large intestine	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation altering degron motif	0.6477
p.S186A	SNU-1040	large intestine	COSMIC	PVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7588
p.C736S	SIDM00867	Glioblastoma	GDSC	VSSSS	DEG_SPOP_SBC_1	745:749	Mutation rewiring degron network	0.0833
p.C736S	DBTRG-05MG	central nervous system	COSMIC	VSSSS	DEG_SPOP_SBC_1	745:749	Mutation rewiring degron network	0.0833
p.S747Y	SIDM01320	Pancreatic Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	745:749	Mutation altering degron motif	0.712
p.S747T	SIDM01320	Pancreatic Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	745:749	Mutation altering degron motif	0.6005
p.I186V	SK-PN-DW	bone	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation altering degron motif	0.7076
p.I186V	SK-PN-DW	bone	COSMIC	PVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7076
p.W744R	COR-L88	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	745:749	Mutation rewiring degron network	0.3056
p.R183C	NCI-H630	large intestine	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation altering degron motif	0.8301
p.R344W	SW403	large intestine	COSMIC	LPLHQE	LIG_APCC_ABBA_1	341:346	Mutation altering degron motif	0.8634
p.A336V	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LPLHQE	LIG_APCC_ABBA_1	341:346	Mutation rewiring degron network	0.1944
p.I186M	HGC-27	stomach	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	182:194	Mutation altering degron motif	0.7618
p.I186M	HGC-27	stomach	COSMIC	PVSST	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7618

Kaplan plot for PCNX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCNX2

UniProt ID: A6NKB5

Entrez ID: 80003

Protein name: Pecanex-like protein 2 (Pecanex homolog protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCNX2 in