DegronMD

Uniprot ID: A6NKB5

Source protein: Pecanex-like protein 2

Source gene: PCNX2

Class: DEG_ODPH_VHL_1

Location: 182:194

E3 ligase: VHL

DEGRON score: 0.9762

ASA_SCORE: 79.3385

COIL: 0.8678

CONS_SCORE: 0.369

DSS_SCORE: 0.4521

HELIX: 0.0317

FCONS_SCORE: 1.1158

RIG_SCORE: 0.6791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S200F	SIDM00516	Melanoma	GDSC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.1667
p.S200F	MZ7-mel	skin	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.1667
p.A199V	SIDM00365	Small Cell Lung Carcinoma	GDSC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.1944
p.A199V	SBC-1	lung	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.1944
p.S186A	SIDM00217	Colorectal Carcinoma	GDSC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.6477
p.S186A	SNU-1040	large_intestine	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.6477
p.I186V	SK-PN-DW	bone	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.7076
p.R183C	NCI-H630	large_intestine	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.8301
p.I186M	HGC-27	stomach	COSMIC	IAPVSSTSPGIKV	DEG_ODPH_VHL_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_ODPH_VHL_1	182:194	IAPVSSTSPGIKV	VHL	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons