DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SPOP_SBC_1

Location: 665:669

E3 ligase: SPOP

DEGRON score: 0.9936

ASA_SCORE: 103.14

COIL: 0.9614

CONS_SCORE: 0.3259

DSS_SCORE: 0.6405

HELIX: 0.0134

FCONS_SCORE: 0.8145

RIG_SCORE: 0.6587

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K662N	TCGA-CC-A7IG	LIHC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.3611
p.K662N	DO52179	LIHC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.3611
p.S676F	TCGA-GN-A269	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1389
p.S676F	DO229446	SKCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.S676F	DO37483	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.S675A	TCGA-HU-A4GH	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1667
p.S675A	DO50339	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.S675A	DO47743	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.Q661K	DO49976	CESC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.6667
p.I679M	DO7938	COAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.Q659H	DO233906	GACA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.Q659H	DO51740	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.P665H	DO228948	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7694
p.T669K	DO228985	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7306
p.P665T	DO229019	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7031
p.T667N	DO229036	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7055
p.Q678P	DO231856	LINC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.P662H	DO45143	LIRI	ICGC	PVTTT	DEG_SPOP_SBC_1	0.3611
p.P668T	DO26424	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7031
p.M676I	DO51276	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.S656A	SIDM00656	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.S656A	SIDM00479	Esophageal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.S656A	SIDM00721	Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.S656A	SIDM00641	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.P659H	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.P659H	ACH-002255	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	0.1667
p.P659H	KARPAS-231	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.S656L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.S656L	ACH-002255	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	0.0833
p.S656L	KARPAS-231	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.V672L	SIDM00220	Ovarian Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.25
p.V672L	ACH-000962	Ovarian Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.25
p.V672L	ACH-001145	Ovarian Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.25
p.V672L	OC-314	ovary	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.25
p.T668A	ACH-002348	Non-Cancerous	CCLE	PVTTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTT

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of PVTTT