DegronMD - Q9Y6V0(PCLO)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S4664I	TCGA-05-4382	LUAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7341
p.S4664I	DO24900	LUAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7341
p.T4655K	TCGA-05-4398	LUAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7306
p.T4655K	DO25847	LUAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7306
p.A1682S	TCGA-05-4417	LUAD	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1667
p.A1682S	DO23570	LUAD	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1667
p.S3456R	TCGA-05-4427	LUAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.0833
p.S3085Y	TCGA-06-2563	GBM	TCGA	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.1111
p.S3085Y	DO11525	GBM	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.1111
p.S895F	TCGA-18-3409	LUSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7982
p.S895F	DO26444	LUSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7982
p.P4671T	TCGA-18-3411	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1667
p.P4671T	TCGA-18-3411	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.P4671T	DO26758	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1667
p.P4671T	DO26758	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.R3455Q	TCGA-18-3414	LUSC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1111
p.A915S	TCGA-18-3417	LUSC	TCGA	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.A915S	TCGA-55-7994	LUAD	TCGA	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.A915S	DO45311	LUAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.A915S	DO26584	LUSC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.S2187F	TCGA-21-1071	LUSC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2778
p.S2187F	DO26918	LUSC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2778
p.S4661F	TCGA-21-1079	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.6871
p.S4661F	TCGA-21-1079	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation altering degron motif	0.7982
p.S4661F	TCGA-CN-A6V7	HNSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.6871
p.S4661F	TCGA-CN-A6V7	HNSC	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation altering degron motif	0.7982
p.S4661F	DO218997	HNSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.6871
p.S4661F	DO218997	HNSC	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation altering degron motif	0.7982
p.S4661F	DO26846	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.6871
p.S4661F	DO26846	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation altering degron motif	0.7982
p.S4661F	DO222521	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.6871
p.S4661F	DO222521	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation altering degron motif	0.7982
p.T1531P	TCGA-2H-A9GR	ESCA	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2778
p.T1531P	TCGA-CG-4466	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2778
p.T1531P	DO38695	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2778
p.T891K	TCGA-2Y-A9HA	LIHC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7306
p.T891K	DO219539	LIHC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7306
p.S1588T	TCGA-33-4587	LUSC	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.S1588T	DO27683	LUSC	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.P3948T	TCGA-43-7656	LUSC	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation altering degron motif	0.5919
p.R882L	TCGA-44-6778	LUAD	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R882L	DO25603	LUAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.T3447M	TCGA-49-4505	LUAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation altering degron motif	0.7423
p.T3447M	TCGA-HF-7132	STAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation altering degron motif	0.7423
p.Q1686R	TCGA-55-7576	LUAD	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2778
p.Q1686R	DO24431	LUAD	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2778
p.V4662F	TCGA-55-A490	LUAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7068
p.V4662F	DO24596	LUAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7068
p.P4668L	TCGA-56-5897	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.25
p.P4668L	TCGA-56-5897	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1389
p.P4668L	DO26453	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.25
p.P4668L	DO26453	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1389
p.G4653C	TCGA-66-2734	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2778
p.G4653C	TCGA-66-2734	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.2222
p.G4653C	TCGA-BF-A1PX	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2778
p.G4653C	TCGA-BF-A1PX	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.2222
p.G4653C	DO26430	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2778
p.G4653C	DO26430	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.2222
p.G4653C	DO51236	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2778
p.G4653C	DO51236	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.2222
p.D2180Y	TCGA-66-2769	LUSC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6214
p.D2180Y	DO26522	LUSC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6214
p.G886V	TCGA-66-2795	LUSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.25
p.G886V	DO26710	LUSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.25
p.P2178H	TCGA-76-6286	GBM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.7694
p.P2178H	DO13552	GBM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.7694
p.D1694E	TCGA-92-8065	LUSC	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.5647
p.D1694E	DO27074	LUSC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.5647
p.T3169S	TCGA-94-A5I6	LUSC	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.T3169S	DO219176	LUSC	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.S1587C	TCGA-95-7567	LUAD	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.3056
p.S1587C	DO25564	LUAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.3056
p.I3178V	TCGA-A5-A0G2	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.5965
p.I3178V	DO41235	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.5965
p.A885T	TCGA-A5-A0G2	UCEC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2222
p.A885T	TCGA-C5-A1MI	CESC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2222
p.A885T	DO6249	CESC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2222
p.A885T	DO41235	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2222
p.A885T	SIDM02059	Colorectal Carcinoma	GDSC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2222
p.R3067I	TCGA-AA-A00N	COAD	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.25
p.R3067I	DO9876	COAD	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.25
p.D3449N	TCGA-AA-A01T	COAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2778
p.R1529L	TCGA-AA-A02Y	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529L	DO7858	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.P2592Q	TCGA-AD-6895	COAD	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7035
p.P2592Q	DO8938	COAD	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7035
p.P779S	TCGA-AF-3913	READ	TCGA	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.P779S	DO36846	READ	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.Q3062H	TCGA-AG-A002	READ	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation altering degron motif	0.647
p.Q3446R	TCGA-AK-3456	KIRC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation altering degron motif	0.6218
p.S3180Y	TCGA-AP-A0LM	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6009
p.S3180Y	DO43306	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6009
p.R3435Q	TCGA-AP-A1DV	UCEC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1389
p.R3435Q	TCGA-CA-6718	COAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1389
p.R3435Q	TCGA-ER-A198	SKCM	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1389
p.R3435Q	TCGA-IG-A51D	ESCA	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1389
p.D1694H	TCGA-AR-A2LE	BRCA	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.7688
p.D1694H	DO1932	BRCA	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.7688
p.V927M	TCGA-AX-A3G9	UCEC	TCGA	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.3056
p.V927M	TCGA-DM-A1D4	COAD	TCGA	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.3056
p.V927M	DO10782	COAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.3056
p.V927M	DO41241	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.3056
p.I912N	TCGA-B0-5099	KIRC	TCGA	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1111
p.I912N	DO16317	KIRC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1111
p.M1701T	TCGA-B5-A0K6	UCEC	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1389
p.M1701T	DO40808	UCEC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1389
p.K897N	TCGA-B5-A1MR	UCEC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2778
p.K897N	DO41758	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2778
p.T3453A	TCGA-B5-A3FA	UCEC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1667
p.K1593T	TCGA-B5-A3FA	UCEC	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation substituting flanking lysine	0.25
p.K1593T	DO23214	LINC	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation substituting flanking lysine	0.25
p.K1593T	DO52402	UCEC	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation substituting flanking lysine	0.25
p.D3179H	TCGA-BA-5555	HNSC	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6577
p.D3179H	DO14220	HNSC	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6577
p.G4669R	TCGA-BF-AAOU	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2222
p.G4669R	TCGA-BF-AAOU	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1111
p.G4669R	DO219460	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2222
p.G4669R	DO219460	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1111
p.S1572F	TCGA-BF-AAP7	SKCM	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.1667
p.S1572F	DO219472	SKCM	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.1667
p.R882Q	TCGA-BR-8680	STAD	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R882Q	TCGA-FR-A726	SKCM	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R882Q	DO48665	SKCM	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R882Q	DO47769	STAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R882Q	ACH-002396	Bone Cancer	CCLE	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R882Q	Sarc9371	bone	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.D3451Y	TCGA-BS-A0UF	UCEC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2222
p.T774A	TCGA-BS-A0UF	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.T774A	DO41488	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.S2595Y	TCGA-BS-A0UV	UCEC	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.712
p.S2595Y	DO42793	UCEC	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.712
p.R904C	TCGA-C5-A7X3	CESC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.R904C	TCGA-CN-6992	HNSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.R904C	DO49893	CESC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.R904C	DO14606	HNSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.K662N	TCGA-CC-A7IG	LIHC	TCGA	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation substituting flanking lysine	0.3611
p.K662N	DO52179	LIHC	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation substituting flanking lysine	0.3611
p.I3959M	TCGA-CK-6746	COAD	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation rewiring degron network	0.0556
p.S911N	TCGA-CN-A498	HNSC	TCGA	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0833
p.S911N	DO52038	HNSC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0833
p.R1530I	TCGA-CN-A63U	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.25
p.R1530I	DO44454	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.25
p.E1698K	TCGA-CV-5966	HNSC	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2222
p.E1698K	DO14950	HNSC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2222
p.E1698K	ACH-000544	Esophageal Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2222
p.S1535P	TCGA-CV-7263	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation altering degron motif	0.6752
p.S1535P	DO14398	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation altering degron motif	0.6752
p.S902L	TCGA-CV-A45Z	HNSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.S902L	DO52064	HNSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.S2190L	TCGA-D1-A103	UCEC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.S2190L	TCGA-EE-A181	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.S2190L	DO37444	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.S2190L	DO42312	UCEC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.S2190L	SIDM01060	Melanoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.S2190L	ACH-000882	Skin Cancer	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.S2190L	IGR-1	skin	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.1944
p.G4647E	TCGA-D3-A2J8	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647E	TCGA-D3-A2J8	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647E	TCGA-EE-A29V	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647E	TCGA-EE-A29V	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647E	TCGA-SY-A9G5	BLCA	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647E	TCGA-SY-A9G5	BLCA	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647E	DO51906	BLCA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647E	DO51906	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647E	DO37778	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647E	DO37778	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647E	DO38006	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647E	DO38006	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.R1529Q	TCGA-D3-A2JE	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	TCGA-EE-A181	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	TCGA-EE-A3JD	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	TCGA-W3-AA1V	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	DO37444	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	DO50299	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	DO51276	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	DO219476	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	SIDM00177	Melanoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	SIDM00140	Melanoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	ACH-000968	Skin Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	ACH-002338	Skin Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	ACH-002510	Skin Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.R1529Q	COLO-792	skin	COSMIC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2222
p.G4666W	TCGA-D3-A2JK	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.3056
p.G4666W	TCGA-D3-A2JK	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1944
p.G4666W	DO230539	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.3056
p.G4666W	DO230539	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1944
p.G4666W	DO37619	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.3056
p.G4666W	DO37619	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1944
p.R3455W	TCGA-D3-A8GI	SKCM	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1111
p.S3180F	TCGA-D3-A8GI	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6871
p.S3180F	TCGA-W3-A824	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6871
p.S3180F	DO229453	SKCA	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6871
p.S3180F	DO50284	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6871
p.S3180F	DO51271	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6871
p.V760E	TCGA-D3-A8GL	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.V760E	DO50287	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.P892R	TCGA-D6-A4Z9	HNSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7512
p.P892R	DO44419	HNSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7512
p.T2579P	TCGA-D7-6822	STAD	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation rewiring degron network	0.0556
p.T2579P	DO38423	STAD	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation rewiring degron network	0.0556
p.D1545E	TCGA-DD-AACZ	LIHC	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1111
p.D1545E	DO52216	LIHC	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1111
p.G3108C	TCGA-DJ-A2PX	THCA	TCGA	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.0833
p.G3108C	DO39683	THCA	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.0833
p.V3181F	TCGA-DK-AA77	BLCA	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.7068
p.V3181F	DO219014	BLCA	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.7068
p.A3056T	TCGA-DM-A1HA	COAD	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2778
p.A3056T	DO8754	COAD	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2778
p.Q2599H	TCGA-DM-A280	COAD	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation rewiring degron network	0.2222
p.Q2599H	DO8256	COAD	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation rewiring degron network	0.2222
p.P4665H	TCGA-DX-A1KU	SARC	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7694
p.P4665H	DO219944	SARC	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.7694
p.P2178L	TCGA-EE-A29M	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6471
p.P2178L	DO222702	MELA	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6471
p.P2178L	DO37404	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6471
p.P2592L	TCGA-EE-A29R	SKCM	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7582
p.P2592L	DO37448	SKCM	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7582
p.G4647R	TCGA-EE-A29V	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647R	TCGA-EE-A29V	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647R	DO222653	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647R	DO222653	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647R	DO222843	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647R	DO222843	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.G4647R	DO38006	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.G4647R	DO38006	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.E1595K	TCGA-EE-A2MJ	SKCM	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.0833
p.E1595K	TCGA-EE-A2MU	SKCM	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.0833
p.E1595K	DO37436	SKCM	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.0833
p.E1595K	DO38099	SKCM	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.0833
p.E1595K	ACH-000987	Skin Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.0833
p.E1595K	Mewo	skin	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.0833
p.P3182S	TCGA-EE-A3AD	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6752
p.P3182S	DO37707	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6752
p.I3058M	TCGA-EI-6506	READ	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation altering degron motif	0.6507
p.I3058M	DO36780	READ	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation altering degron motif	0.6507
p.S4674N	TCGA-EJ-5515	PRAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.0833
p.S4674N	DO36251	PRAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.0833
p.S3172Y	TCGA-EO-A22X	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.2778
p.S3172Y	DO222798	COCA	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.2778
p.S3172Y	DO43907	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.2778
p.T3169N	TCGA-EO-A22X	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.T3169N	DO43907	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.S2175F	TCGA-FR-A3YN	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.25
p.S2175F	DO38111	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.25
p.S2175F	SIDM01768	Melanoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.25
p.S2175F	ACH-000899	Skin Cancer	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.25
p.P3192S	TCGA-FS-A1ZA	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1111
p.P3192S	DO37551	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1111
p.P1525S	TCGA-FS-A1ZP	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1111
p.P1525S	DO37703	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1111
p.P3096L	TCGA-FS-A4F0	SKCM	TCGA	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation altering degron motif	0.7582
p.P3096L	DO37891	SKCM	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation altering degron motif	0.7582
p.E3189K	TCGA-FT-A3EE	BLCA	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.E3189K	DO720	BLCA	ICGC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.E3189K	Sarc9371	bone	COSMIC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.1944
p.E3450K	TCGA-FW-A3R5	SKCM	TCGA	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.25
p.G3073R	TCGA-FW-A3R5	SKCM	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.0833
p.G3073R	DO37406	SKCM	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.0833
p.D1678N	TCGA-GC-A3OO	BLCA	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.0556
p.D1678N	DO518	BLCA	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.0556
p.T2591I	TCGA-GN-A265	SKCM	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7078
p.T2591I	DO227657	COCA	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7078
p.T2591I	DO37491	SKCM	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation altering degron motif	0.7078
p.D2180N	TCGA-GN-A266	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.5821
p.D2180N	DO37432	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.5821
p.E1544K	TCGA-GN-A266	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1389
p.E1544K	DO37432	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1389
p.S676F	TCGA-GN-A269	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1389
p.S676F	DO229446	SKCA	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1389
p.S676F	DO37483	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1389
p.S675A	TCGA-HU-A4GH	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.S675A	DO50339	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.S675A	DO47743	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.V2176I	TCGA-IG-A97H	ESCA	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2778
p.Q3939H	TCGA-IN-A6RO	STAD	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation rewiring degron network	0.25
p.S3092L	TCGA-IR-A3LK	CESC	TCGA	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.3056
p.S3092L	DO44299	CESC	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.3056
p.Q3941K	TCGA-JW-A5VL	CESC	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation rewiring degron network	0.3056
p.M3068L	TCGA-L5-A43E	ESCA	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2222
p.M3068L	DO50355	ESAD	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2222
p.M3068L	DO233773	GACA	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2222
p.K758N	TCGA-MU-A8JM	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation substituting flanking lysine	0.1944
p.K758N	DO49002	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation substituting flanking lysine	0.1944
p.T2174I	TCGA-QQ-A8VF	SARC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2222
p.T2174I	DO220258	SARC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2222
p.E900D	TCGA-QS-A5YQ	UCEC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1944
p.E900D	DO49073	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1944
p.V3181L	TCGA-S7-A7X1	PCPG	TCGA	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6765
p.S4670C	TCGA-S9-A6WM	LGG	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1944
p.S4670C	TCGA-S9-A6WM	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0833
p.S4670C	DO50200	LGG	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1944
p.S4670C	DO50200	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0833
p.P2605L	TCGA-SX-A71S	KIRP	TCGA	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation rewiring degron network	0.0556
p.P2605L	DO49778	KIRP	ICGC	PGTPTDS	DEG_SCF_FBW7_1	2589:2595	Mutation rewiring degron network	0.0556
p.G3057R	TCGA-UC-A7PF	CESC	TCGA	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.3056
p.G3057R	DO49987	CESC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.3056
p.S781Y	TCGA-VQ-A8P2	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.0556
p.S781Y	DO51761	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.0556
p.S4652L	TCGA-VR-A8EY	ESCA	TCGA	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.25
p.S4652L	TCGA-VR-A8EY	ESCA	TCGA	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1944
p.P1697A	TCGA-VR-A8EY	ESCA	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.25
p.M3956I	TCGA-W3-AA1V	SKCM	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation rewiring degron network	0.1389
p.S902P	TCGA-XK-AAIW	PRAD	TCGA	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.S902P	DO51407	PRAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.S3091F	TCGA-YD-A9TA	SKCM	TCGA	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2778
p.S3091F	DO219503	SKCM	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2778
p.K922N	DO218990	BLCA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.6918
p.K922N	DO50406	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.6918
p.K922N	DO233235	GACA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.6918
p.K922N	DO38635	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.6918
p.P776S	DO233957	BPLL	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1944
p.E2168G	DO225331	BRCA	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.0556
p.R930T	DO4921	BRCA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation substituting flanking lysine	0.3333
p.D1575E	DO222953	BTCA	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.25
p.Q661K	DO49976	CESC	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation blocking phosphorylation signal	0.6667
p.I679M	DO7938	COAD	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0556
p.D771Y	DO9940	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.7325
p.A901S	DO8463	COAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1667
p.I926T	DO8264	COAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7078
p.I775N	DO230312	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation substituting flanking lysine	0.3333
p.K893N	DO230346	COCA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.6918
p.P3071T	DO228098	EOPC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.1389
p.K1593N	DO50447	ESAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation substituting flanking lysine	0.25
p.F923Y	DO234157	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7528
p.E1576A	DO234270	ESAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.K922Q	DO234270	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.6944
p.R1579T	DO234166	ESAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation altering degron motif	0.7876
p.K761R	DO234191	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation substituting flanking lysine	0.2778
p.K761R	SIDM01269	Esophageal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation substituting flanking lysine	0.2778
p.E933G	DO234315	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1389
p.F923V	DO223116	ESCA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7068
p.P776R	DO222786	ESCA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1944
p.Q898H	DO228491	GACA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.25
p.R930G	DO233245	GACA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation substituting flanking lysine	0.3333
p.S3099F	DO233289	GACA	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation altering degron motif	0.7982
p.F923C	DO233288	GACA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7108
p.F923C	DO47879	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7108
p.T891I	DO233885	GACA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7078
p.S885N	DO233855	GACA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2222
p.Q659H	DO233906	GACA	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.Q659H	DO51740	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.S921T	DO220519	KICH	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7116
p.S1537N	DO20604	KIRC	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation altering degron motif	0.7069
p.K910R	DO20516	KIRC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0556
p.P763S	DO51835	LGG	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2222
p.G880C	DO228217	LICA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.G880C	SIDM00652	Small Cell Lung Carcinoma	GDSC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.G880C	ACH-000780	Lung Cancer	CCLE	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.G880C	NCI-H1105	lung	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0833
p.V767A	DO228597	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.5825
p.V767A	DO232761	PBCA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.5825
p.P665H	DO228948	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation altering degron motif	0.7694
p.T884N	DO228974	LICA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1944
p.T3060N	DO228976	LICA	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation altering degron motif	0.7055
p.T669K	DO228985	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation altering degron motif	0.7306
p.S929G	DO232008	LICA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.25
p.P665T	DO229019	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation altering degron motif	0.7031
p.S4670Y	DO229028	LICA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1944
p.S4670Y	DO229028	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0833
p.S4648Y	DO229028	LICA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1389
p.S4648Y	DO229028	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0833
p.T3065K	DO229022	LICA	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.3056
p.P763Q	DO229022	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2222
p.Q1592K	DO229026	LICA	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.1667
p.Q887K	DO229034	LICA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.2778
p.T667N	DO229036	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation altering degron motif	0.7055
p.A772E	DO229036	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation blocking phosphorylation signal	0.75
p.Q1686K	DO229038	LICA	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2778
p.A4657T	DO50869	LICA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation altering degron motif	0.6028
p.A4657T	DO50869	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation altering degron motif	0.7139
p.L915I	DO219582	LIHC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.R3050P	DO231580	LINC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.1111
p.S2186L	DO23104	LINC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.3056
p.S2186L	SIDM01175	Other Sarcomas	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.3056
p.S2186L	ACH-002309	Sarcoma	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.3056
p.S2186L	SW684	soft tissue	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.3056
p.Q678P	DO231856	LINC	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.G3055V	DO231906	LINC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.25
p.L1691M	DO23478	LINC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.5999
p.G935V	DO23378	LINC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0833
p.P662H	DO45143	LIRI	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation substituting flanking lysine	0.3611
p.P4671R	DO45091	LIRI	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1667
p.P4671R	DO45091	LIRI	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0556
p.D935Y	DO25545	LUAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0833
p.T1689K	DO25104	LUAD	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.6195
p.E882D	DO24190	LUAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.R764Q	DO23740	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.R764Q	DO222491	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.R764Q	DO37679	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.R764Q	DO50286	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.R764Q	DO48665	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.R764Q	DO38111	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.R764Q	DO51249	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.D759H	DO23907	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.P3096A	DO26469	LUSC	ICGC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation altering degron motif	0.7503
p.P668T	DO26424	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation altering degron motif	0.7031
p.E933Q	DO219144	LUSC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1389
p.S4670P	DO228253	MALY	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1944
p.S4670P	DO228253	MALY	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0833
p.R1527K	DO220857	MELA	ICGC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1667
p.R1527K	SIDM01066	Melanoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1667
p.R1527K	ACH-000650	Skin Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1667
p.R1527K	IGR-37	skin	COSMIC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.1667
p.S769L	DO220877	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation altering degron motif	0.7667
p.G910E	DO220877	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0556
p.S924L	DO220895	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7667
p.S924L	DO222662	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7667
p.S924L	DO37444	SKCM	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7667
p.S924L	DO219503	SKCM	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7667
p.H4651Y	DO220891	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2222
p.H4651Y	DO220891	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1667
p.H4651Y	DO222632	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.2222
p.H4651Y	DO222632	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.1667
p.P916S	DO220899	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.2222
p.R1579K	DO222402	MELA	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation altering degron motif	0.7237
p.I778V	DO222420	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.P4654S	DO222837	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.3056
p.P4654S	DO222837	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.25
p.P763L	DO30010	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2222
p.S881Y	DO232761	PBCA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1111
p.A902V	DO51407	PRAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.A902V	DO51299	SKCM	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1389
p.Y884H	DO46869	RECA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1944
p.S4670F	DO229465	SKCA	ICGC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1944
p.S4670F	DO229465	SKCA	ICGC	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.0833
p.D757N	DO37651	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.0556
p.P879S	DO37814	SKCM	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.0556
p.M676I	DO51276	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1389
p.G778E	DO51272	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1389
p.K922I	DO38839	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7531
p.Y936S	DO38839	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0556
p.Y766C	DO219774	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.K912N	DO219773	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1111
p.A901V	DO223282	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1667
p.F923L	DO43041	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.6981
p.K922T	DO41903	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7306
p.E774D	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.25
p.P1523L	SIDM01123	Prostate Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.0556
p.P1523L	SIDM00253	Neuroblastoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.0556
p.P1523L	ACH-000177	Prostate Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.0556
p.P1523L	ACH-002284	Neuroblastoma	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.0556
p.P1523L	NCI-H660	prostate	COSMIC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.0556
p.P1523L	NB6	autonomic ganglia	COSMIC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.0556
p.F932C	SIDM00955	Melanoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1667
p.F932C	ACH-000812	Skin Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1667
p.F932C	COLO-783	skin	COSMIC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1667
p.P916L	SIDM00973	Melanoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.2222
p.P916L	ACH-000827	Skin Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.2222
p.P916L	WM793B	skin	COSMIC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.2222
p.E1576K	SIDM01156	Small Cell Lung Carcinoma	GDSC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.E1576K	SIDM01203	Other Solid Cancers	GDSC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.E1576K	ACH-000890	Lung Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.E1576K	ACH-002291	Embryonal Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.E1576K	SW1271	lung	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.E1576K	NTERA-2_cl_D1	testis	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2778
p.L766H	SIDM01020	Plasma Cell Myeloma	GDSC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.L766H	ACH-000380	Myeloma	CCLE	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.L766H	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.3056
p.D3432N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.0556
p.D3432N	SIDM01483	Melanoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.0556
p.D3432N	SIDM01149	Small Cell Lung Carcinoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.0556
p.E1590K	SIDM00189	Melanoma	GDSC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2222
p.E1590K	ACH-002098	Skin Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2222
p.E1590K	CP67-MEL	skin	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	1578:1586	Mutation rewiring degron network	0.2222
p.V4673M	SIDM00967	Ovarian Carcinoma	GDSC	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.1111
p.A3187T	SIDM00120	Prostate Carcinoma	GDSC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.25
p.A3187T	ACH-000979	Prostate Cancer	CCLE	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.25
p.A3187T	DU-145	prostate	COSMIC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.25
p.S656A	SIDM00656	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.S656A	SIDM00479	Esophageal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.S656A	SIDM00721	Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.S656A	SIDM00641	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.D3454Y	SIDM00789	Colorectal Carcinoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1389
p.D3454Y	HCT-15	large intestine	COSMIC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1389
p.P2178T	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.7031
p.P2178T	ACH-000372	Leukemia	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.7031
p.P2178T	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.7031
p.V3089A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2222
p.V3089A	ACH-001669	Leukemia	CCLE	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2222
p.V3089A	ACH-002238	Leukemia	CCLE	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2222
p.V3089A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2222
p.M759I	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.M759I	ACH-000733	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.M759I	NCI-H1838	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.1111
p.P659H	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.P659H	ACH-002255	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.P659H	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.1667
p.S656L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.S656L	ACH-002255	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.S656L	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.0833
p.L3165F	SIDM00719	Small Cell Lung Carcinoma	GDSC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.0833
p.S3164N	SIDM00719	Small Cell Lung Carcinoma	GDSC	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.0556
p.T888S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.3056
p.T888S	ACH-002059	Leukemia	CCLE	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.3056
p.T888S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.3056
p.P896T	SIDM00282	Colorectal Carcinoma	GDSC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.3056
p.P896T	ACH-000998	Colon/Colorectal Cancer	CCLE	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.3056
p.P896T	CW-2	large intestine	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.3056
p.P2178S	SIDM00694	Other Solid Cancers	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6752
p.P2178S	SIDM00673	Breast Carcinoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation altering degron motif	0.6752
p.E1696K	SIDM00333	Endometrial Carcinoma	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2778
p.E1696K	ACH-000988	Endometrial/Uterine Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2778
p.E1696K	MFE-319	endometrium	COSMIC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.2778
p.M1701I	SIDM01088	Endometrial Carcinoma	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1389
p.M1701I	ACH-000965	Endometrial/Uterine Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1389
p.M1701I	RL95-2	endometrium	COSMIC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.1389
p.A3056S	SIDM00498	Colorectal Carcinoma	GDSC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2778
p.A3056S	ACH-000970	Colon/Colorectal Cancer	CCLE	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2778
p.A3056S	SNU-C5	large intestine	COSMIC	ISTPQYS	DEG_SCF_FBW7_1	3058:3064	Mutation rewiring degron network	0.2778
p.A915T	SIDM01146	Gastric Carcinoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.A915T	ACH-000932	Gastric Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.A915T	NCI-SNU-1	stomach	COSMIC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1944
p.T2174A	SIDM00214	Colorectal Carcinoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2222
p.T2174A	ACH-000955	Colon/Colorectal Cancer	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2222
p.T2174A	SNU-407	large intestine	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	2178:2185	Mutation rewiring degron network	0.2222
p.S3436N	SIDM00567	Other Solid Cancers	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1667
p.S3436N	ACH-000776	Brain Cancer	CCLE	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1667
p.S3436N	ONS-76	central nervous system	COSMIC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.1667
p.S3091P	SIDM01043	Other Sarcomas	GDSC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2778
p.S3091P	ESS-1	endometrium	COSMIC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.2778
p.G3108V	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.0833
p.G3108V	ACH-000916	Lung Cancer	CCLE	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.0833
p.G3108V	NCI-H1573	lung	COSMIC	VATPTPS	DEG_SCF_FBW7_1	3093:3099	Mutation rewiring degron network	0.0833
p.S1532T	SIDM00217	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.3056
p.S1532T	SNU-1040	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.3056
p.V672L	SIDM00220	Ovarian Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.25
p.V672L	ACH-000962	Ovarian Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.25
p.V672L	ACH-001145	Ovarian Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.25
p.V672L	OC-314	ovary	COSMIC	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation rewiring degron network	0.25
p.D3449E	SIDM01205	Acute Myeloid Leukemia	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2778
p.D3449E	SIDM01195	Acute Myeloid Leukemia	GDSC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2778
p.D3449E	ACH-000406	Leukemia	CCLE	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2778
p.D3449E	ACH-002314	Leukemia	CCLE	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2778
p.D3449E	TUR	haematopoietic and lymphoid tissue	COSMIC	DSGVQT	DEG_SCF_TRCP1_1	3442:3447	Mutation rewiring degron network	0.2778
p.T922A	SIDM00528	Breast Carcinoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7139
p.T922A	ACH-000934	Breast Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7139
p.T922A	MDA-MB-361	breast	COSMIC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation altering degron motif	0.7139
p.S1690R	SIDM01611	Endometrial Carcinoma	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.6316
p.S1690R	ACH-000996	Endometrial/Uterine Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation altering degron motif	0.6316
p.G935A	SIDM01472	Hepatocellular Carcinoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0833
p.G935A	ACH-000471	Liver Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.0833
p.P1697L	SIDM01525	Acute Myeloid Leukemia	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	1688:1694	Mutation rewiring degron network	0.25
p.T3186K	ACH-000068	Lymphoma	CCLE	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation rewiring degron network	0.2778
p.P3942H	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation altering degron motif	0.7694
p.T763A	ACH-000982	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2222
p.M3957T	ACH-001030	Bone Cancer	CCLE	PTPTPQPS	DEG_SCF_FBW7_1	3942:3949	Mutation rewiring degron network	0.1111
p.T3177S	ACH-001558	Lung Cancer	CCLE	TAETIDSVPTL	DEG_COP1_1	3174:3184	Mutation altering degron motif	0.6005
p.D1539N	ACH-001566	Skin Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1533:1537	Mutation rewiring degron network	0.2778
p.P4654H	ACH-001664	Gastric Cancer	CCLE	TSAGSSSVPSP	DEG_COP1_1	4655:4665	Mutation rewiring degron network	0.3056
p.P4654H	ACH-001664	Gastric Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	4657:4661	Mutation rewiring degron network	0.25
p.T668A	ACH-002348	Non-Cancerous	CCLE	PVTTT	DEG_SPOP_SBC_1	665:669	Mutation altering degron motif	0.7139
p.T763I	MZ7-mel	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation rewiring degron network	0.2222
p.K913N	SW684	soft tissue	COSMIC	PTTPQET	DEG_SCF_FBW7_1	920:926	Mutation rewiring degron network	0.1389
p.I903R	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation rewiring degron network	0.1111
p.I772V	NCI-N87	stomach	COSMIC	VSSSS	DEG_SPOP_SBC_1	767:771	Mutation blocking phosphorylation signal	0.75
p.E892K	Mewo	skin	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	889:895	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCLO

UniProt ID: Q9Y6V0

Entrez ID: 27445

Protein name: Protein piccolo (Aczonin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCLO in