DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SPOP_SBC_1

Location: 4657:4661

E3 ligase: SPOP

DEGRON score: 0.9198

ASA_SCORE: 70.02

COIL: 0.8942

CONS_SCORE: 0.6887

DSS_SCORE: 0.7499

HELIX: 0.0216

FCONS_SCORE: 0.8912

RIG_SCORE: 0.4838

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4661F	TCGA-21-1079	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	0.7982
p.S4661F	TCGA-CN-A6V7	HNSC	TCGA	AGSSS	DEG_SPOP_SBC_1	0.7982
p.S4661F	DO218997	HNSC	ICGC	AGSSS	DEG_SPOP_SBC_1	0.7982
p.S4661F	DO26846	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	0.7982
p.S4661F	DO222521	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.7982
p.A4657T	DO50869	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.7139
p.P4654S	DO222837	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.25
p.P4654H	ACH-001664	Gastric Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.25
p.G4653C	TCGA-66-2734	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	0.2222
p.G4653C	TCGA-BF-A1PX	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	0.2222
p.G4653C	DO26430	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	0.2222
p.G4653C	DO51236	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	0.2222
p.G4666W	TCGA-D3-A2JK	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	0.1944
p.G4666W	DO230539	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1944
p.G4666W	DO37619	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1944
p.S4652L	TCGA-VR-A8EY	ESCA	TCGA	AGSSS	DEG_SPOP_SBC_1	0.1944
p.H4651Y	DO220891	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1667
p.H4651Y	DO222632	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1667
p.P4668L	TCGA-56-5897	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	0.1389
p.P4668L	DO26453	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1389
p.G4669R	TCGA-BF-AAOU	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	0.1111
p.G4669R	DO219460	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1111
p.S4670C	TCGA-S9-A6WM	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	0.0833
p.S4670C	DO50200	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	0.0833
p.S4670Y	DO229028	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 25 of 41 entries

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Drug responses associated with PCLO mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AGSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	138:142	AGSSS	SPOP	0.9944	More...
Q12797	Aspartyl/asparaginyl beta-hydroxylase	DEG_SPOP_SBC_1	25:29	AGSSS	SPOP	0.9939	More...
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SPOP_SBC_1	1288:1292	AGSSS	SPOP	0.9988	More...
O75508	Claudin-11	DEG_SPOP_SBC_1	194:198	AGSSS	SPOP	0.8946	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	185:189	AGSSS	SPOP	0.9844	More...
Q5VW00	DDB1- and CUL4-associated factor 12-like protein 2	DEG_SPOP_SBC_1	20:24	AGSSS	SPOP	0.9965	More...
Q9Y238	Deleted in lung and esophageal cancer protein 1	DEG_SPOP_SBC_1	31:35	AGSSS	SPOP	0.5085	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1376:1380	AGSSS	SPOP	0.9974	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	691:695	AGSSS	SPOP	0.9332	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	978:982	AGSSS	SPOP	0.9867	More...
Q96A65	Exocyst complex component 4	DEG_SPOP_SBC_1	250:254	AGSSS	SPOP	0.9981	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	261:265	AGSSS	SPOP	0.9927	More...
Q9BX10	GTP-binding protein 2	DEG_SPOP_SBC_1	30:34	AGSSS	SPOP	0.9919	More...
Q92831	Histone acetyltransferase KAT2B	DEG_SPOP_SBC_1	408:412	AGSSS	SPOP	0.9856	More...
O95251	Histone acetyltransferase KAT7	DEG_SPOP_SBC_1	8:12	AGSSS	SPOP	0.9992	More...
Q86YZ3	Hornerin	DEG_SPOP_SBC_1	511:515	AGSSS	SPOP	0.9551	More...
O60303	Katanin-interacting protein	DEG_SPOP_SBC_1	861:865	AGSSS	SPOP	0.9839	More...
P05787	Keratin, type II cytoskeletal 8	DEG_SPOP_SBC_1	447:451	AGSSS	SPOP	0.9964	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_SPOP_SBC_1	1709:1713	AGSSS	SPOP	0.7232	More...
Q16644	MAP kinase-activated protein kinase 3	DEG_SPOP_SBC_1	370:374	AGSSS	SPOP	0.8767	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	792:796	AGSSS	SPOP	0.987	More...
P43362	Melanoma-associated antigen 9	DEG_SPOP_SBC_1	52:56	AGSSS	SPOP	0.9728	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	546:550	AGSSS	SPOP	0.9719	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	334:338	AGSSS	SPOP	0.9856	More...
Q86VE0	Myb-related transcription factor, partner of profilin	DEG_SPOP_SBC_1	174:178	AGSSS	SPOP	0.9993	More...

Showing 1 to 25 of 55 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSSS

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of AGSSS