DegronMD - Q8TBC5(ZSCAN18)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L187P	TCGA-21-1077	LUSC	TCGA	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6471
p.L187P	DO26725	LUSC	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.6471
p.A63G	TCGA-86-8585	LUAD	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.A63G	DO24850	LUAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.S69G	TCGA-94-A5I6	LUSC	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0556
p.S69G	DO219176	LUSC	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0556
p.P59H	TCGA-A6-5666	COAD	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.7694
p.A184T	TCGA-B5-A3FC	UCEC	TCGA	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7139
p.A184T	DO41871	UCEC	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7139
p.A184T	SIDM01113	Other Sarcomas	GDSC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7139
p.A184T	ACH-000939	Sarcoma	CCLE	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7139
p.A184T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7139
p.A184T	SK-UT-1	soft tissue	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7139
p.A198V	TCGA-B7-5816	STAD	TCGA	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.A198V	TCGA-D7-A6EY	STAD	TCGA	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.A198V	TCGA-OR-A5J5	ACC	TCGA	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.A63V	TCGA-BR-4369	STAD	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.A63V	DO233210	GACA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.A63V	DO38659	STAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.P59S	TCGA-D3-A8GB	SKCM	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.6752
p.R53H	TCGA-DI-A1BU	UCEC	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.8244
p.R53H	DO218227	BTCA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.8244
p.R53H	DO42023	UCEC	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.8244
p.R53H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.8244
p.A176T	TCGA-DK-AA6L	BLCA	TCGA	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944
p.A176T	DO219002	BLCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944
p.L150P	TCGA-DU-A5TT	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.L150P	DO44564	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.S66F	TCGA-EE-A2MD	SKCM	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1389
p.S66F	DO222434	MELA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1389
p.S66F	DO37851	SKCM	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1389
p.Q143H	TCGA-FD-A6TC	BLCA	TCGA	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.Q143H	DO49755	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.R139H	TCGA-JY-A93D	ESCA	TCGA	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.R139H	DO222439	BTCA	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.R139H	DO230956	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.R139H	DO224579	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.G143C	DO219049	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6489
p.R148W	DO49102	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2778
p.R148W	DO37259	READ	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2778
p.Q139K	DO10100	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.A177T	DO230311	COCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2222
p.A177T	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2222
p.A177T	ACH-000787	Lung Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2222
p.A177T	LXF-289	lung	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2222
p.V64A	DO222576	COCA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1944
p.R132W	DO229005	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0556
p.P50S	DO234191	ESAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.25
p.S183L	DO234402	ESAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7667
p.P144T	DO20496	KIRC	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7031
p.T49K	DO229026	LICA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.Q152K	DO23138	LINC	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.S69C	DO23398	LINC	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0556
p.G184A	DO25242	LUAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.754
p.G176V	DO26052	LUAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944
p.E188K	DO220878	MELA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7022
p.E188K	DO229453	SKCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7022
p.G140E	DO220902	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.7222
p.P193S	DO222453	MELA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944
p.D137Y	DO50708	ORCA	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.D198N	DO229453	SKCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.G175W	DO37746	SKCM	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1667
p.L148F	DO50287	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2778
p.R63S	DO47623	SKCM	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.P193L	DO223907	SKCM	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944
p.P193L	OE19	oesophagus	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944
p.A152T	DO51747	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.R53Q	DO48040	STAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.7329
p.S141G	DO47813	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.P173T	DO47925	STAD	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.A179S	DO229140	THCA	ICGC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778
p.K141M	SIDM00313	Hodgkin's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.K141M	ACH-000702	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.K141M	L-1236	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.P67S	SIDM00422	Hodgkin's Lymphoma	GDSC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1111
p.P67S	ACH-001203	Lymphoma	CCLE	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1111
p.P67S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1111
p.E146Q	SIDM01063	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6744
p.E146Q	ACH-000190	Unknown	CCLE	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6744
p.E146Q	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6744
p.G155V	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.G155V	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.G155V	ACH-000590	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.G155V	ACH-001137	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.G155V	NCI-H1993	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.C173Y	SIDM00220	Ovarian Carcinoma	GDSC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.C173Y	ACH-000962	Ovarian Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.C173Y	ACH-001145	Ovarian Cancer	CCLE	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.C173Y	OC-314	ovary	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.P67H	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1111
p.P67H	ACH-002337	Lung Cancer	CCLE	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1111
p.A65D	ACH-000884	Skin Cancer	CCLE	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1667
p.A45T	SNU-407	large intestine	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1111
p.P179L	RCC-FG2	kidney	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.2778
p.P46H	TUR	haematopoietic and lymphoid tissue	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.1389
p.L173F	TGW	autonomic ganglia	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1111
p.R155G	JHH-2	liver	COSMIC	AGSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.A180T	SNU-407	large intestine	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.3056
p.D44N	NCI-H2009	lung	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0833
p.P44L	RCC-FG2	kidney	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0833
p.P181H	TUR	haematopoietic and lymphoid tissue	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation altering degron motif	0.7694
p.D176G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSETPWLS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZSCAN18

UniProt ID: Q8TBC5

Entrez ID: 65982

Protein name: Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZSCAN18 in