DegronMD

Uniprot ID: Q8TBC5

Source protein: Zinc finger and SCAN domain-containing protein 18

Source gene: ZSCAN18

Class: LIG_APCC_ABBAyCdc20_2

Location: 53:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.739

ASA_SCORE: 78.8714

COIL: 0.6861

CONS_SCORE: 0.6136

DSS_SCORE: 0.2865

HELIX: 0.0971

FCONS_SCORE: 1.0003

RIG_SCORE: 0.8266

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A63G	TCGA-86-8585	LUAD	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A63G	DO24850	LUAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S69G	TCGA-94-A5I6	LUSC	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S69G	DO219176	LUSC	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P59H	TCGA-A6-5666	COAD	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.7694
p.A63V	TCGA-BR-4369	STAD	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A63V	DO233210	GACA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A63V	DO38659	STAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P59S	TCGA-D3-A8GB	SKCM	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.6752
p.R53H	TCGA-DI-A1BU	UCEC	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R53H	DO218227	BTCA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R53H	DO42023	UCEC	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R53H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.8244
p.S66F	TCGA-EE-A2MD	SKCM	TCGA	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S66F	DO222434	MELA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S66F	DO37851	SKCM	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V64A	DO222576	COCA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P50S	DO234191	ESAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.25
p.T49K	DO229026	LICA	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S69C	DO23398	LINC	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R63S	DO47623	SKCM	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R53Q	DO48040	STAD	ICGC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.7329
p.P67S	SIDM00422	Hodgkin's Lymphoma	GDSC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P67S	ACH-001203	Lymphoma	CCLE	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P67S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P67H	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P67H	ACH-002337	Lung Cancer	CCLE	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A65D	ACH-000884	Skin Cancer	CCLE	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A45T	SNU-407	large_intestine	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P46H	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D44N	NCI-H2009	lung	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P44L	RCC-FG2	kidney	COSMIC	REFVYQE	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: REFVYQE

Degron related mutations and impact score

Drug responses associated with ZSCAN18 mutations

All proteins holding degron of REFVYQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBC5	Zinc finger and SCAN domain-containing protein 18	LIG_APCC_ABBAyCdc20_2	53:59	REFVYQE	APC,CDC20,FZR1	0.739	More...